Androgen‐induced lncRNA POTEF‐AS1 regulates apoptosis‐related pathway to facilitate cell survival in prostate cancer cells |
| |
| Authors: | Aya Misawa Ken‐ichi Takayama Tetsuya Fujimura Yukio Homma Yutaka Suzuki Satoshi Inoue |
| |
| Affiliation: | 1. Department of Anti‐Aging Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan;2. Department of Functional Biogerontology, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan;3. Department of Urology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan;4. Department of Medical Genome Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Chiba, Japan;5. Division of Gene Regulation and Signal Transduction, Research Center for Genomic Medicine, Saitama Medical University, Hidaka, Japan |
| |
| Abstract: | Although long non‐coding RNAs (lncRNAs) have been associated with a variety of cancers, the interplay between lncRNAs and androgen receptor signaling in prostate cancer is still unclear. We identified an androgen‐dependent lncRNA, POTEF‐AS1, whose expression was regulated by androgen receptor in two androgen‐dependent cells by using directional RNA sequencing analysis. POTEF‐AS1 promoted cell growth, repressed genes related to the Toll‐like receptor signaling and apoptosis pathways, and inhibited apoptosis in docetaxel‐treated LNCaP cells. These findings suggest that POTEF‐AS1 would play a key role in the progression of prostate cancer by repressing Toll‐like receptor signaling. |
| |
| Keywords: |
AR
lncRNA prostate cancer
TLR3
TNFSF10
|
|
|
