| 复方胃利散抗大鼠消化性溃疡的作用 |
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| 引用本文： | 关冬梅,周晓棉,李靖菲,孟静娟,徐永鹏,曹颖林.复方胃利散抗大鼠消化性溃疡的作用[J].沈阳药科大学学报,2009,26(3):225-229. |
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| 作者姓名： | 关冬梅 周晓棉 李靖菲 孟静娟 徐永鹏 曹颖林 |
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| 作者单位： | 关冬梅,周晓棉,李靖菲,徐永鹏,曹颖林,GUAN Dong-mei,ZHOU Xiao-mian,LI Jing-fei,XU Yong-peng,CAO Ying-lin(沈阳药科大学,生命科学与生物制药学院,辽宁,沈阳,110016);孟静娟,MENG Jing-juan(中国医科大学,附属第四医院,辽宁,沈阳,110032)
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| 摘 要： | 目的考察复方胃利散(compound Weili powder,FFWLP)对动物实验性溃疡模型的影响。方法建立乙醇致大鼠胃溃疡模型,幽门结扎型大鼠胃溃疡模型,盐酸半胱氨酸致大鼠十二指肠溃疡模型及乙酸致大鼠十二指肠溃疡模型。结果复方胃利散对乙醇致大鼠胃溃疡有保护作用;对幽门结扎致大鼠胃溃疡有保护作用;对乙酸、盐酸半胱氨酸致大鼠十二指肠溃疡有明显的治疗作用,并能降低胃液酸性,显著升高十二指肠溃疡模型大鼠的肠黏膜PGE2含量。结论复方胃利散有很好的抗消化性溃疡的作用。
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| 关 键 词： | 复方胃利散 消化性溃疡 乙醇 幽门结扎 盐酸半胱氨酸 |
| 收稿时间： | 2008-6-19 |
Effect of Fufang Weili powder on experimental peptic ulcer in rats |
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| GUAN Dong-mei,ZHOU Xiao-mian,LI Jing-fei,MENG Jing-juan,XU Yong-peng,CAO Ying-lin.Effect of Fufang Weili powder on experimental peptic ulcer in rats[J].Journal of Shenyang Pharmaceutical University,2009,26(3):225-229. |
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| Authors: | GUAN Dong-mei ZHOU Xiao-mian LI Jing-fei MENG Jing-juan XU Yong-peng CAO Ying-lin |
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| Institution: | (1.School of Life Science and Biopharmaceutics , Shenyang Pharmaceutical University, Shenyang 110016,China; 2.Pharmaceutical Preparation Section Fourth Hospital,China Medical University ,Shenyang 110032 ） |
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| Abstract: | Objective To observe the effect of Fufang Weili powder (WLP) on peptic ulcer in rats. Methods The four models of ethanol-induced and pyloric ligated gastric ulcer in rats, cysteamine-induced and acetic acid-induced duodenal ulcer in rats were established. Results Fufang Weili powder (WLP) significantly protected stomach from gastric ulcer damage induced by ethanol, pyloric ligation. Meanwhile, Fufang Weili powder (WLP) showed an obvious curative effect on duodenal ulcer caused by cysteamine, acetic acid; furthermore, it significantly reduced acidity of the gastric juice and increased the content of PGE2 in mucous membrane. Conclusion Fufang Weili powder can inhibit the experimental peptic ulcer in rats. |
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| Keywords: | Fufang Weili powder peptic ulcer ethanol pyloric ligation cysteamine" target="_blank">')">cysteamine " target="_blank">')"> |
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