| 健心汤对心力衰竭患者血清细胞因子网络和神经内分泌的影响 |
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| 引用本文： | 赵海滨,沈承玲,徐向青.健心汤对心力衰竭患者血清细胞因子网络和神经内分泌的影响[J].上海中医药大学学报,2004,18(1):17-20. |
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| 作者姓名： | 赵海滨 沈承玲 徐向青 |
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| 作者单位： | 1. 北京中医药大学附属东方医院,北京,100078
2. 北京中医药大学,北京,100029 |
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| 基金项目： | 广东省博士后基金资助项目([2002]523) |
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| 摘 要： | 为探讨充血性心力衰竭患者(CHF)血清肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)、一氧化氮(NO)、内皮素(ET-1)、心钠素(ANP)的改变及健心汤的临床效应。将66例CHF患者随机分为试验组和对照组。对照组采用常规治疗,试验组在常规治疗的基础上加用益气温阳、活血利水中药健心汤。两组疗程均为四周。在治疗前后测定TNF-α、IL-6、NO、ET-1、ANP和心功能的变化。结果:治疗后两组血清TNF-α、IL-6、NO、ET-1、ANP水平均明显下降(P<0.05,或P<0.01),且试验组较对照组降低更为显著(P<0.05)。治疗后两组心功能均有明显改善(P<0.05,或P<0.01)。提示健心汤可能通过调控细胞因子的水平、减轻机体神经内分泌的过度激活,起到防止和逆转心室重构,改善心功能的作用。
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| 关 键 词： | 健心汤 心力衰竭 血清 细胞因子网络 神经内分泌 活血利水法 |
| 文章编号： | 1008-861X(2004)01-0017-04 |
Effect of "Jianxin Decoction" on Serum Cell Factors Network and Neuroendocrine in Patients with Congestive Heart Failure |
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| Dongfang Hospital Affiliated to Beijing University of Traditional Chinese Medicine,ZHAO Hai-bin Beijing University of Traditional chinese Medicine SHEN Cheng-ling XU Xiang-qing.Effect of "Jianxin Decoction" on Serum Cell Factors Network and Neuroendocrine in Patients with Congestive Heart Failure[J].Acta Universitatis Traditionis Medicalis Sinensis Pharmacologiaeque Shanghai,2004,18(1):17-20. |
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| Authors: | Dongfang Hospital Affiliated to Beijing University of Traditional Chinese Medicine ZHAO Hai-bin Beijing University of Traditional chinese Medicine SHEN Cheng-ling XU Xiang-qing |
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| Institution: | Dongfang Hospital Affiliated to Beijing University of Traditional Chinese Medicine
ZHAO Hai-bin Beijing University of Traditional chinese Medicine SHEN Cheng-ling XU Xiang-qing |
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| Abstract: | |
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| Keywords: | Congestive heart failure "Jianxin Decoction" cell network neuroendocrine |
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