SLE患者外周血单个核细胞中IL-6 IL-10表达研究 |
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引用本文: | 陈志强,李子仁,范江,岳晓玉,徐文严. SLE患者外周血单个核细胞中IL-6 IL-10表达研究[J]. 中国皮肤性病学杂志, 2000, 14(1): 4-5 |
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作者姓名: | 陈志强 李子仁 范江 岳晓玉 徐文严 |
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作者单位: | 中国医学科学院中国协和医科大学皮肤病研究所南京 210042 |
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基金项目: | 高等院校博士学科点专项科研基金资助课题9502084 |
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摘 要: | 目的 探讨系统性红斑狼疮(SLE)患者中Th2型细胞因子mRNA的表达。方法 用逆转录-多聚酶链反应(RT-PCR)法检测了10例正常人和15例活动期SLE患者外周血单个核细胞(PBMC)中白介素6(IL-6)和白介素10(IL-10)mRNA表达的水平。结果 与正常相比,活动期SLE患者PBMC中IL-6和IL-10mRNA的表达水平均增高(均P〈0.01)。结论 SLE患者中Th2型细胞因子I
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关 键 词: | 系统性红斑狼疮 白细胞介素 mRNA RT-PCR |
修稿时间: | 1999-01-22 |
The IL-6 IL-10 Expression in the Peripheral Mononuclear Cell of the Patients with Systemic Lupus Erythematosus. |
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Abstract: | Objective To investigate the mRNA expression of Th2 type cytokines in SLE patients.Methods Applying RT PCR technique to semiquantitatively analyse the mRNA expression of IL 6 and IL 10 in the PBMCs from 10 normal controls and 15 SLE patients.Results Compared with normal controls,the mRNA expression of IL 6 and IL 10 in SLE PBMCs was significantly increased( P <0.01,both).Conclusion The Th2 type cytokine IL 6 IL 10 expression in active SLE patients is up regulated,which might play some roles in the pathogenesis of SLE. |
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Keywords: | Lupus erythematosus systemic IL 6 IL 10mRNA RT PCR |
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