| 埃索美拉唑与奥美拉唑治疗反流性食管炎的疗效观察 |
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| 引用本文： | 彭兰,冯琦,李昌平,马春华,章静. 埃索美拉唑与奥美拉唑治疗反流性食管炎的疗效观察[J]. 西部医学, 2009, 21(6): 962-963,966 |
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| 作者姓名： | 彭兰 冯琦 李昌平 马春华 章静 |
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| 作者单位： | 1. 绵阳市中心医院消化内科,四川绵阳,621000
2. 泸州医学院附属医院消化内科,四川泸州,646000 |
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| 摘 要： | 目的探讨新一代质子泵抑制剂埃索美拉唑对反流性食管炎（RE）的临床疗效。方法将108倒经胃镜证实的RE患者随机分为两组，A组58例，给予埃索美拉唑40mg，每日1次；B组50例，予以奥美拉唑20mg，每日2次，两组疗程均为8周。两组均同时加用促动力药莫沙比利，分别于治疗4、6、8周后记录烧心、反酸和胸骨后灼痛等症状记分，判断疗效。并于8周后复查胃镜，观察胃镜下愈合率。结果两组治疗均有效，而A组A级、B级食管炎疗效、烧心症状改善均优于B组。结论埃索美拉唑治疗RE疗效确切。
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| 关 键 词： | 反流性食管炎 埃索美拉唑 奥美拉唑 质子泵抑制剂 |
The effect of esomeprazole on reflux esophagitis |
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| Affiliation: | PENG Lan, FENG Qi, LI Chang-ping, et al. (Department of Gastroenterology, The Central Hospital of Mianyang , Mianyang 621000, Sichuan, China) |
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| Abstract: | Objective To investigate the clinical effect of new proton pump inhibitor esomeprazole on reflux esophagitis. Methods 108 patients with reflux esophagitis diagnosed by endoscopy were randomly divided into group A （n= 58） and group B（n= 50）. Group A was treat with esomeprazole. Group B was treated with omeprazole. All patients add- ed mosapride. The effects were evaluated with symptoms and gastroscop. Results After 8 weeks treatment, the total symptom apparent effect rate was 86.2% in group A and 56. 0% in group B （P〈0. 05%） . The total symptom improvement rate was 96.6% in group A and 73.0% in group B（P〈0.05）. There were significant differences in endoscope amelioration between the two groups. Conclusion Esomepraxole is effective in treatment of reflux esophagitis. |
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| Keywords: | Reflux esophagitis Esomeprazole Omeprazole Protom pump inhibitor |
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