The link between abdominal obesity and the metabolic syndrome |
| |
Authors: | Liza K. Phillips Johannes B. Prins |
| |
Affiliation: | (1) Diamantina Institute for Cancer, Immunology, and Metabolic Medicine, University of Queensland, Princess Alexandra Hospital, Level 2, Building 35, Ipswich Road, Woolloongabba, 4102, Queensland, Australia |
| |
Abstract: | The clustering of cardiovascular risk factors associated with abdominal obesity is well established. Although currently lacking a universal definition, the metabolic syndrome describes a constellation of metabolic abnormalities, including abdominal obesity, and was originally introduced to characterize a population at high cardiovascular risk. Adipose tissue is a dynamic endocrine organ that secretes several inflammatory and immune mediators known as adipokines. Dysregulation of adipokine secretion, free fatty acid toxicity, and the site-specific differences in abdominal (visceral) versus subcutaneous fat support abdominal obesity as a causal factor mediating the insulin resistance, increased risk of diabetes, and cardiovascular disease in the metabolic syndrome. |
| |
Keywords: | |
本文献已被 PubMed SpringerLink 等数据库收录! |
|