Investigation of Pharmaceutical Oil/Water Microemulsions by Small-Angle Scattering |
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Authors: | Shukla Anuj Janich Martin Jahn Konstanze Krause Annett Kiselev Mikael A Neubert Reinhard H H |
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Institution: | (1) Department of Physics, Optics Group, Martin Luther University Halle-Wittenberg, 06099 Halle/Saale, Germany;(2) Interdisciplinary Centre of Material Science, Martin Luther University Halle-Wittenberg, 06099 Halle/Saale, Germany;(3) Department of Pharmacy, Institute of Pharmaceutics and Biopharmaceutics, Martin Luther University Halle-Wittenberg, 06120 Halle/Saale, Germany;(4) Frank Laboratory of Neutron Physics, JINR, Dubna, 141980, Russia |
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Abstract: | Purpose. Stable oil/water (o/w) microemulsions are very effective vehicle systems for dermal administration of drugs having no or low skin penetration. These systems, consisting of oils, a blend of a high and a low HLB surfactant, and a hydrophilic phase (propylene glycol/water), were developed using pharmaceutically acceptable components.
Methods. In this paper, the droplet size of these microemulsions was characterized by means of dynamic light scattering (DLS) and small-angle neutron scattering (SANS). Furthermore, different size parameters obtained by DLS and SANS experiments were compared and discussed.
Results. Extremely small droplet radii of approximately 10 nm could be observed. A good agreement between the data of DLS and SANS experiments was found. The kind of oil only marginally influences the droplet size.
Conclusions. Particle size determination via scattering techniques is a useful tool to characterize droplets in microemulsions for dermal drug delivery. |
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Keywords: | dynamic light scattering o/w microemulsions small-angle neutron scattering |
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