| 对氨基水杨酸钠治疗慢性锰中毒机制的研究 |
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| 引用本文： | 纪淑琴 胡万达. 对氨基水杨酸钠治疗慢性锰中毒机制的研究[J]. 广西医科大学学报, 1995, 12(4): 477-483 |
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| 作者姓名： | 纪淑琴 胡万达 |
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| 作者单位： | 广西医科大学劳动职业病教研室!南宁530021(纪淑琴，胡万达，姜岳明，韦小敏，黄波)，广西医科大学药理学教研室(洪息君)，广西南宁市卫生防疫站(郭建霞)，广西肿瘤(黄超培) |
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| 摘 要： | 用对氨基水杨酸钠（ＰＡＳ－Ｎａ）治疗用氯化锰腹腔注射的大鼠和小鼠。结果：过量锰对动物机体的毒性表现为多个系统的异常反应，但用ＰＡＳ－Ｎａ治疗后，能降低其血液和各器官组织中过量蓄积锰的含量；能增加其胆汗和粪中锰的排出量；能便被过量锰所影响动物的行为、免疫功能、酶活性、脑神经递质水平以及脑组织学等改变恢复正常或接近正常，提示ＰＡＳ－Ｎａ对治疗慢性锰中毒具有明显疗效。
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| 关 键 词： | 对氨基水杨酸钠 锰中毒 神经递质 免疫功能 |
A STUDY ON THE EFFECT OF TREATINGMANGANESE POISONING WITH SODIUMPARA-AMINOSALICYLATA ACID |
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| Ji Shuqin,Hu Wanda,Jiang Yueming,et al. A STUDY ON THE EFFECT OF TREATINGMANGANESE POISONING WITH SODIUMPARA-AMINOSALICYLATA ACID[J]. Journal of Guangxi Medical University, 1995, 12(4): 477-483 |
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| Authors: | Ji Shuqin Hu Wanda Jiang Yueming et al |
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| Affiliation: | Dept. of Industrial Hygiene and Occupational Diseases Nanning 530021 |
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| Abstract: | In traperitoneal injections of MnCl24H2O produced functional disturbances in several systems of the rats and mice. Such manganese poisoning was treated with Sodium Fara-aminosalicylate Acid (PAS-Na). After subehronic treatment, the manganese content in the blood and tissues decreased. While the manganese content in the bile and feces increased. The behavior of the animals, functions of the immune system,activity of the enzymes, level of the monoaminoneurotransmitter and the histology of the brain, which were af-fected by excessive manganese might be restored to normal or nearly normal. The results indi-cate that PAS-Na appears to be an effective drug for the treatment of chronic manganese pois. |
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| Keywords: | sodium para-aminosalicylate acid (PAS-Na) manganese neurotramsmitter enzyme immunization. |
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