角果木二萜Tagalsin的抗肿瘤作用

目的 探讨中国南海角果木二萜成分Tagalsin的抗肿瘤作用。方法建立小鼠Lewis肺癌和H2肝癌实体瘤模型及H22肝癌腹水瘤模型。随机分为角果木二萜Tagalsin高、中、低剂量组（20、10、5mg／kg）、空白对照组、环磷酰胺（CTX）组。建模后24h开始给药，角果木二萜Tagalsin高、中、低剂量组连续灌胃给予不同浓度Tagalsin7d，空白对照组给予同体积生理盐水，CTX组连续腹腔注射CTX（10mg／kg）7d。末次给药24h后处死动物，计算抑瘤率、脏器指数、生命延长率，流式细胞术检测凋亡率。结果角果木二萜Tagalsin在5—20mg／kg内，对小鼠实体瘤Lewis和H22的抑瘤率分别为12．62％-43．69％和24．49％-48．30％。Tagalsin可明显延长Hz腹水瘤小鼠生存时间；降低Lewis肺癌及H。肝癌小鼠胸腺指数，升高肝脏指数；肿瘤细胞的凋亡率随着角果木二萜Tagalsin剂量的增加而增高（P〈0．05或〈0．01）。结论角果木二萜Tagalsin对小鼠Lewis和H22移植瘤的生长具有明显的抑制作用，其机制可能与其诱导细胞凋亡有关。

Anti-tumor effect of biterpenes tagalsin in ceriops tagal

Objective To study the anti-tumor effect of biterpenes tagalsin of ceriops tagal collected from the South China Sea.Methods The subcutaneously transplanted solid tumor models with Lewis and hepatoma-22 and the ascitic tumor models with hepatoma-22 were established.All the models were divided randomly into 5 groups: 5,10 and 20 mg/kg biterpenes tagalsin groups,saline and CTX(10 mg/kg),each of which was composed of 10 mice.The biterpenes tagalsin were given by intragastric administration,the CTX by intraperit...