Effect of cesium,lithium, and rubidium on some actions of morphine

The effect of cesium, lithium, and rubidium chlorides on the analgesic action of morphine (in the vocalization test) and on the course of dependence on it (by the two bottle test) was investigated. The chlorides were shown to reduce both the threshold of the pain response and the duration of analgesia produced by morphine. Cesium chloride was most active in this respect. All the compounds studied reduced the coefficient of morphine preference. The greatest effect was observed with cesium chloride, which reduced the preference coefficient to one-fortieth of the control level.Laboratory of Pharmacology of the Nervous System, Institute of Pharmacology, Academy of Medical Sciences of the USSR, Moscow. (Presented by Academician of the Academy of Medical Sciences of the USSR V. V. Zakusov.) Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 86, No. 7, pp. 42–44, July, 1978.