加减小柴胡汤治疗小儿感染后咳嗽邪郁少阳证临床研究

目的：观察加减小柴胡汤治疗小儿感染后咳嗽（PIC） 邪郁少阳证的临床效果。方法：将120例PIC邪郁少阳证患儿以随机平行对照法分为小柴胡汤组和西医组，每组60例。西医组给予常规西医治疗，小柴胡汤组在西医组基础上给予加味小柴胡汤治疗。治疗7 d后比较2组临床疗效，并比较2组治疗前后中医证候积分、咳嗽症状评分、炎症反应及免疫功能。结果：小柴胡汤组总有效率95.00%，高于西医组81.67% （P＜0.05）。治疗后，2组中医证候积分均降低（P＜0.05），且小柴胡汤组低于西医组（P＜0.05）。治疗后，2组日间、夜间咳嗽症状评分均降低（P＜0.05），且小柴胡汤组低于西医组（P＜0.05）。治疗后，2组血清白细胞介素-6 （IL-6）、转化生长因子-β1 （TGF-β1）、肿瘤坏死因了-α （TNF-α） 及免疫球蛋白E （IgE） 水平均降低（P＜0.05），且小柴胡汤组低于西医组（P＜0.05）。结论：针对PIC邪郁少阳证患儿给予加减小柴胡汤治疗可提高治疗效果，缓解临床症状，减轻咳嗽程度及机体炎症反应，提高免疫功能，从而有效改善病情。

Clinical Study on Modified Xiaochaihu Decoction for Postinfectious Cough in Childrenwith Accumulation of Pathogenic Factors in Shaoyang Syndrome

Abstract： Objectives： To observe the clinical effect of modified Xiaochaihu Decoction forpostinfectious cough (PIC) in children with accumulation of pathogenic factors in shaoyang syndrome.Methods： A total of 120 cases of PIC children with accumulation of pathogenic factors in shaoyangsyndrome were divided into the Xiaochaihu Decoction group and the western medicine group according tothe random number table method ， with 60 cases in each group. The western medicine group was treatedwith routine western medicine，and the Xiaochaihu Decoction group was additionally treated with modifiedXiaochaihu Decoction based on the treatment of the western medicine group. Clinical effects after 7 days oftreatment were compared between the two groups. Traditional Chinese medicine syndrome scores，coughsymptom scores， inflammatory responses， and immune function were compared before and aftertreatment between the two groups. Results： The total effective rate was 95.00% in the XiaochaihuDecoction group， higher than that of 81.67% in the western medicine group (P＜0.05). After treatment，traditional Chinese medicine syndrome scores in the two groups were decreased (P＜0.05)，and the scoresin the Xiaochaihu Decoction group were lower than those in the western medicine group (P＜0.05). Aftertreatment，the scores of daytime cough and nighttime cough in the two groups were decreased (P＜0.05)，and the scores in the Xiaochaihu Decoction group were lower than those in the western medicine group (P＜0.05). After treatment，the levels of serum interleukin-6 (IL-6)，transforming growth factor- β1 (TGF-β1)，tumor necrosis factor-α(TNF-α)，and immunoglobulin E (IgE) in the two groups were decreased (P＜0.05)，and the above levels in the Xiaochaihu Decoction group were lower than those in the western medicinegroup (P＜0.05). Conclusion： For PIC children with accumulation of pathogenic factors in shaoyangsyndrome， modified Xiaochaihu Decoction can improve curative effects， relieve clinical symptoms，reduce cough degree and body inflammatory responses， and enhance immune function， so as toeffectively improve the condition.