Subchronic effects of feeding graded levels of cocoa butter to rats |
| |
| Affiliation: | 1. Department of Medicine, College of Physicians & Surgeons, Columbia University, New York, NY, United States;2. Department of Biostatistics, Mailman School of Public Health, Columbia University, New York, NY, United States;3. Centre for Quantitative Medicine, Duke-NUS Medical School, Singapore;4. Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States;5. Flow Cytometry Shared Resource, Herbert Irving Comprehensive Cancer Center, Columbia University, New York, NY, United States;6. Biomarkers Core Laboratory, Irving Institute for Clinical and Translational Research, Columbia University, New York, NY, United States;7. Department of Pathology and Cell Biology, College of Physicians & Surgeons, Columbia University, New York, NY, United States;8. Department of Cardiology, Skåne University Hospital, Malmö, Sweden;9. Department of Clinical Sciences, Lund University, Malmö, Sweden;10. Center of Emergency Medicine, Skåne University Hospital, Malmö, Sweden;11. Cardiology Division, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States |
| |
| Abstract: | The effects of feeding graded levels of cocoa butter (0, 10, 20, and 30%) in a semi-purified diet to weanling male and female rats for 90 days were evaluated. Serum cholesterol concentrations determined at days 0, 30, 60, and 90 demonstrated significant decreases (P≤0.05) for all cocoa butter treated male rats at day 60. Consumption of cocoa butter containing diets did not have a deleterious effect on the normal growth of Sprague-Dawley rats. Histological evaluations of selected tissues at the termination of the study indicated no pathological abnormalities due to the consumption of cocoa butter. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
