早发冠心病的发病机制与预防的研究进展

冠心病的传统危险因素包括高血压、糖尿病、血脂异常和高胆固醇血症、肥胖与超重、吸烟、饮酒等等。随着冠心病发病的人群越来越多,发病趋势也逐渐呈现年轻化。《美国胆固醇成人治疗组教育计划第三次指南》(NCEP ATP-III)将早发冠心病(PCHD)定义为发病年龄男性＜55岁、女性＜65岁的冠心病患者。因此,早发冠心病目前已经成为国内外的一个研究热点。除了冠心病的传统危险因素外,如何探究早发冠心病新的发病机制及预测因素更是做好早发冠心病一级预防的重要举措。近年来,国内外就此做了大量的临床与基础研究,本文就既往研究进行综述。旨在详尽探讨早发冠心病的最新发病机制和相关预测因素,为临床医学提供一定的参考价值,做好一级预防,为早发冠心病患者提供更好的预后。

Research progress on pathogenesis and prevention of premature coronary heart disease

The conventional risk factors associated with coronary heart disease (CHD) encompass hypertension, diabetes mellitus, dyslipidemia, hypercholesterolemia, obesity, smoking, and alcohol consumption. With an escalating incidence of CHD, a discernible shift towards a younger age of onset is evident. The Third Report of the National Cholesterol Education Program Adult Treatment Panel III (NCEP ATP-III) defines premature coronary heart disease (PCHD) as manifestation in males <55 years and females <65 years. Consequently, PCHD has emerged as a focal point in both domestic and international investigative pursuits. In addition to the established risk factors, there is a paramount need to elucidate novel pathogenic mechanisms and predictive factors governing PCHD. This necessitates concerted efforts in primary prevention. This manuscript conducts a comprehensive review of antecedent research endeavors, with the primary objective of meticulously scrutinizing the latest pathogenic intricacies and pertinent predictive factors associated with PCHD. The overarching aim is to contribute substantive insights to the realm of clinical medicine, fortify primary prevention paradigms, and ameliorate prognostic outcomes for individuals afflicted with early-onset coronary heart disease.