SERUM CONCENTRATIONS OF DIGOXIN ENTRAPPED IN LIPOSOMES AFTER INTRAVENOUS ADMINISTRATION IN DOGS |
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Authors: | M. W. Fountain W. D. Pedersoli W. R. Ravis V. K. Ganjam |
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Affiliation: | *Department of Veterinary Physiology and Pharmacology, Auburn University, Auburn, Alabama, U.S.A.;School of Pharmacy, Auburn University, Auburn, Alabama, U.S.A. |
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Abstract: | 1. Digoxin was associated into phosphotidylcholine liposomes at concentrations of 28–33 mol% in Hank's Buffer, pH 7.4 at 28°C. 2. Digoxin-liposomes (digoxin concentration 0.022 mg/kg per dog per day) administered intravenously in five adult male dogs attained therapeutic serum concentrations (0.7–3.0 ng/ml) beginning with day 1 of administration. 3. Digoxin serum concentrations obtained by intravenous digoxin-liposomes compared favorably with normal oral digoxin administration (0.022 mg/kg per dog per day) in all 5 dogs monitoring serum digoxin levels for 7 days showed no significant (P<0.05) differences in mean serum digoxin concentrations ± s.e.m. on 6 of 7 days of treatments. |
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Keywords: | igoxin intravenous administration liposomes oral administration phosphotidylcholine |
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