Genomic sequence of a Japanese encephalitis virus isolate from southern China |
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Authors: | Jiu-Song Zhang Qiu-Min Zhao Pan-He Zhang Na Jia and Wu-Chun Cao |
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Institution: | (1) State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, 20 Dong Da-Street, Fengtai District, 100071 Beijing, People’s Republic of China |
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Abstract: | We determined the complete nucleotide sequence of a Japanese encephalitis virus (JEV) isolate (designated SH17M-2007) from
a pool of Culex tritaeniorhynchus collected in southern China in 2007. The genome consisted of 10,965 nucleotides and included a single open reading frame
(10,296 nucleotides) that encodes a 3,432-amino-acid polyprotein. The SH17M-2007 had 97.3 to 98.4% nucleotide identity with
two Korean strains (KV1899, K94P05) and two Japanese strains (Ishikawa, JEV/sw/Mie/40/2004), but only 88.8% identity with
the Chinese vaccine strain SA14-14-2. Five unique amino acid substitutions including one in the envelope (E) protein (GluE-306-Lys) were found in the SH17M-2007 strain. Phylogenetic relationships based on the full-length nucleotide sequences were similar
to those based on the E gene. |
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