| 系统性红斑狼疮患者CD62P、CD63表达与SLEDAI相关性分析 |
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| 引用本文： | 陈明玉,周再高,曾抗,孙乐栋,易正山.系统性红斑狼疮患者CD62P、CD63表达与SLEDAI相关性分析[J].中国麻风皮肤病杂志,2006,22(3):185-186. |
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| 作者姓名： | 陈明玉 周再高 曾抗 孙乐栋 易正山 |
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| 作者单位： | 南方医科大学南方医院,广州,510515 |
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| 摘 要： | 目的:观察系统性红斑狼疮(SLE)患者外周血血小板膜蛋白CD62P、CD63的表达,并探讨CD62P、CD63与SLE疾病活动指数(SLEDAI)之间的相关性。方法:采用流式细胞术对10例SLE患者外周血CD62P、CD63进行检测分析,以20例正常人作为对照。同时对该10例SLE患者进行SLEDAI评分。结果:SLE患者CD62P、CD63表达较对照组显著增高(P<0.01),CD62P表达与SLEDAI之间具有显著相关性(r=0.840,P=0.002)。结论:CD62P、CD63在SLE患者外周血中表达显著增高,CD62P可作为评估SLE疾病活动程度指标。
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| 关 键 词： | 系统性红斑狼疮 CD62P CD63 流式细胞术 SLE疾病活动指数 |
| 收稿时间： | 2005-06-22 |
| 修稿时间： | 2005-09-20 |
Expression of CD62P and CD63 in patients with systemic lupus erythematosus and their correlation with SLEDAI |
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| Chen Ming, Zhou Zaigao, Zeng Kang , et al.Expression of CD62P and CD63 in patients with systemic lupus erythematosus and their correlation with SLEDAI[J].China Journal of Leprosy and Skin Diseases,2006,22(3):185-186. |
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| Authors: | Chen Ming Zhou Zaigao Zeng Kang |
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| Institution: | Departmenl of Rheumatology and Hematology, Nanfang Hospital, Nanfang Medical University , Guartgzhou , 510515 |
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| Abstract: | Objective: To measure the expression of platelet membrane proteins(CD62P and CD63) of peripheral blood in patients with systemic lupus erythematosus(SLE) and to assess their correlation with SLEDAI.Methods: The expressions of CD62P and CD63 in 10 SLE cases and 20 healthy volunteers were measured by flow cytometry(FCM),and the results were compared with SLEDAI score.Results: The expressions of CD62P and CD63 were significantly higher in SLE than those in healthy volunteers(P<0.01).CD62P was positively correlated with SLEDAI score(P<0.05).(Conclusion): The expressions of CD62P and CD63 in peripheral blood were significantly higher in patients with SLE and CD62P can be regarded as an indicator in evaluating the activity of SLE. |
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| Keywords: | systemic lupus erythematosus CD62P CD63 flow cytometry SLEDAI |
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