太子健对哮喘豚鼠白细胞介素-5 P-选择素的影响

目的　观察太子健 对反复诱发哮喘的哮喘豚鼠血中白细胞介素 (IL) - 5、黏附分子 P-选择素的影响。方法　将豚鼠随机分为正常组、模型组、地塞米松组、太子健 高剂量和低剂量组 5组 ,后 4组分别用卵蛋白致敏 15 d后 ,再用卵蛋白反复诱发哮喘 ,正常组用生理盐水代替 ,同时 ,正常组和模型组灌服生理盐水 ,其余 3组分别灌服地塞米松、高剂量和低剂量太子健 ,予以治疗 ,连续 15 d。结果　太子健 可减少血中 IL- 5、黏附分子 P-选择素的含量。结论　太子健 可以影响 IL- 5、P-选择素对炎症细胞的调节作用 ,从而减轻气道慢性变应性炎症 ,具有一定的抗哮喘复发的作用。

Study on effect of taizijian Ⅱ on interleukin-5 and P-selectin of asthmatic guinea pigs

Objective Investigating the effect of taizijian Ⅱ on interleukin-5 and P-selectin in blood of asthmatic guinea pigs.Methods Forty guinea pigs were randomly divided into 5 groups.After having been sensitized with egg albumin,guinea pigs were induced to suffer asthmatic attack repeatedly with egg albumin in model group,dexamethasone (DXM) group,taizijian Ⅱ large dose group and small dose group.Normal group received physiological saline.At the same time,guinea pigs were treated with physiological saline in normal group and model group,and those were treated respectively with DXM,taizijiam Ⅱ large dose and small dose in the other three groups for 15 days.Results Taizijian Ⅱ decreasd interleukin-5 and P-selectin in blood.Conclusion Taizijian Ⅱ can relieve the chronic allergic airway inflammation,and stop children′s asthma recurrence.