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卵巢子宫内膜样癌HER-2/neu的表达
引用本文:冷金花,郎景和.卵巢子宫内膜样癌HER-2/neu的表达[J].现代妇产科进展,1996,5(2):104-106.
作者姓名:冷金花  郎景和
摘    要:目的研究卵巢子宫内膜样癌HER-2/neu的表达以及与临床病理特征和预后的关系。方法应用HER-2/neu单克隆抗体免疫组化技术对卵巢子宫内膜样癌28例进行HER-2/neu癌基因蛋白测定。结果13例细胞浆染色阳性,占46.4%,Ⅰ期肿瘤阳性率为20.0%,Ⅱ~Ⅳ期肿瘤阳性率为52.2%,手术有残留肿瘤者HER-2/neu的表达率是62.5%,无残留肿瘤者HER-2/neu表达率是25.0%,差异有显著性(P=0.049)。HER-2/neu表达与发病年龄、CA125水平、组织学分级及淋巴转移无关。术后随诊6~96个月,平均31.3个月,HER-2/neu阳性者术后死亡率是38.5%,HER-2/neu阴性者术后死亡率是21.4%。结论HER-2/neu阳性者与卵巢子宫内膜样癌的不良预后有一定的关系。

关 键 词:卵巢肿瘤,卵巢子宫内膜样癌,癌基因,HER-2/neu

Immunohistochemical studies on the expression of HER-1/neu oncoprotein in endometrioid carcinoma of the ovary
Abstract:To determine the expression of EGFR expression of FIER-2/neu in endometrioid carcinoma a of the ovary and its relationship to clinicopathologic features and prognosis.Methods Expression of HER-2/neu oncoprotein was studied by immunohistochemistry in paraffin-embedded tumor tissues from 28 patients with endometrioid carcinoma of the ovary.Results 13 (46. 4 %) cases were stained positively with monoclonal antibody Ab2. Tumors with advanced stage were likely to have a high HER-2/neu expression. In addition ,a significantly higher expression rate (P= 0. 049) was observed in patients with residual tumors (10/16 , 62. 5%) than patients without residual tumors ( 3/12 ,25. 0% ) . There was no correlation between HER-2/neu immunostaining and age at diagnosis, CA125 titer, grade and lymph node metastases.Patients whose tumors had HER-2/neu overexpression were likely to have a high mortality ( 5i13 , 38. 5%) than patients without HER-2/neu protein overexpression (3/14 . 21. 4 % ).Conclusion HER-2/neu expression was related to residual tumors and deserves futher evaluation as a prognostic marker in endometrioid carcinoma of the ovary.
Keywords:Ovarian neoplasms  Endometrioid carcinoma of the ovary  HER-2/neu
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