| 子宫内膜癌p53蛋白过度表达与性激素受体阳性的关系 |
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| 引用本文： | 徐廷香 王剑波. 子宫内膜癌p53蛋白过度表达与性激素受体阳性的关系[J]. 现代妇产科进展, 1996, 5(3): 224-226 |
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| 作者姓名： | 徐廷香 王剑波 |
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| 作者单位： | 解放军１４５医院，第四军医大学，莱阳卫校 |
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| 摘 要： | 目的：研究子宫内膜癌ｐ５３蛋白过度表达与性激素受体阳性的关系。方法：收集４５例子宫内膜癌手术标本，采用多种ＰＡＰ免疫组化方法进行检测。结果：４５例宫内膜癌中１４例（３１．１％）ｐ５３蛋白过度表达，其中１１例雌、孕激素受体阴性，而在ｐ５３阴性的３１例中２７例雌、孕激素受体阳性。在子宫内膜癌中ｐ５３蛋白过度表达与雌、孕激素受体呈负相关（Ｐ＜０．０１）。结论：部分子宫内膜癌的发生可能与雌激素受体无关，而与ｐ５３蛋白过度表达有关。
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| 关 键 词： | 子宫内膜癌；p53蛋白；受体，雌激素；受体，孕激素 |
The p53 overexpression in endometrial cancer correlates with hormone receptor positivity. |
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| Xu Tingxiang,Li Xiqi,Wang Jianbo,et al. The p53 overexpression in endometrial cancer correlates with hormone receptor positivity.[J]. Current Advances In Obstetrics and Gynecology, 1996, 5(3): 224-226 |
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| Authors: | Xu Tingxiang Li Xiqi Wang Jianbo et al |
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| Abstract: | Objective To research the relationships betweenp 53 protein overexpression and estrogen receptor (ER) and progesterone receptor (PR) in endometrial cancer. Methods A total of 45 samples of endometrial cancer with many repeated PAP immunological method were tested. Results Overexpression of p 53 protein was found in 31.3%(14/15) cases of endometrial cancer.ER and PR expression were found none in 11 of 14 cases with p 53 overexpression.They presented in 27 of 31 cases with p 53 negative tumors ( P <0.01).Inverse correlation of p 53 overexpression with ER and PR expression revealed in endometrial cancer. Conclusion A part of endometrial cancer presumably unrelates with ER expression while relates to the p 53 protein overexpression. |
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| Keywords: | Endometrial cancer:p 53 protein Receptor estrogen Receptor progesterone |
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