血清抗子宫内膜抗体测定对子宫内膜异位症诊断价值的研究

目的：评价血清抗子宫内膜抗体测定子宫内膜异位症（内异症）的诊断价值。方法：用ＥＬＩＳＡ检测内异症２５例（内异症组）、妇科良性疾病２１例（妇病组）及正常育龄妇女１８例（正常组）血清中的抗子宫内膜抗体（ＥＭＡｂ）。结果：内异症组１４例血清ＥＭＡｂ阳性、占５６％。妇病组１例阳性、占４．８％。正常组２例阳性、占１１．１％。内异症组与两对照组的阳性率差异有显著性（Ｐ＜０．００５）。两对照组间阳性率差异无显著性。测定血清ＥＭＡｂ诊断内异症的敏感性为５６％。特异性为９２．３％。血清ＥＭＡｂ阳性率与内异症的严重程度及月经周期无相关性。结论：血清ＥＭＡｂ的测定有助于内异症的定性诊断。

Study on the evaluation of determining serum EMAb for the diagnosis of endometriosis.

Objective To study on the evaluation of determining serum EMAb for the diagnosis of endometriosis. Methods The serum samples of 25 patients with endometrosis(EM group),21 patients with benign gynecologic disorders(G group)and 18 normal fertile women (N group) were tested by using an Enzyme linked immunosorbent Assay(ELISA)for the presence of endometrial antibodies(EMAb). Results EMAb positive cases were found in 14 patients of EM group(56%),in one patient of G group(4.8%),and in 2 women of N group(11.1%).The positive rate between the EM group and the two control groups was significantly different (P<0.005),but there was no significant difference between the two control groups.The sensitivity rate of EMAb in EM group was 56%,and the specificity rate was 92.3%.There were no correlation found between the severity of endometriosis and the positive rate of EMAb as well as the positive rate of EMAb and the menstrual cycle.The cause of pseudo positive mass was analyzed and discussed. Conclusion The determination of serum EMAb is helpful in making qualitative diagnosis of endometriosis.