| 丝裂原活化蛋白激酶信号转导通路与精子活动力 |
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| 引用本文： | 丁玉芹（综述）,姜宏（审校）. 丝裂原活化蛋白激酶信号转导通路与精子活动力[J]. 国外医学(计划生育．生殖健康分册), 2009, 28(4): 249-251 |
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| 作者姓名： | 丁玉芹（综述） 姜宏（审校） |
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| 作者单位： | 安徽医科大学解放军临床学院生殖中心; |
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| 摘 要： | 丝裂原活化蛋白激酶(MAPK)属于丝/苏氨酸蛋白激酶,激活后可参与调节细胞生长、发育、分化、凋亡等一系列生命活动。MAPK转导通路的一些组成部分,如细胞因子:白细胞介素6(IL-6)、成纤维细胞生长因子(FGF);蛋白激酶C(PKC);细胞外信号调节激酶(ERK)和p38及底物精子微管蛋白等直接或间接调节精子的活动力。MAPK信号通路的研究对探讨弱精子症发生的分子机制,寻求弱精子症新治疗途径有意义。
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| 关 键 词： | 丝裂原活化蛋白激酶 信号转导 精子活动力 男性不育 |
Mitogen-activated Protein Kinase Signal Transduction Pathway and Sperm Motility |
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| DING Yu-Qin,JIANG Hong. Reproductive Medicine Center,the PLA Clinical College of Anhui Medical University,Hefei ,China. Mitogen-activated Protein Kinase Signal Transduction Pathway and Sperm Motility[J]. , 2009, 28(4): 249-251 |
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| Authors: | DING Yu-Qin JIANG Hong. Reproductive Medicine Center the PLA Clinical College of Anhui Medical University Hefei China |
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| Affiliation: | DING Yu-Qin,JIANG Hong. Reproductive Medicine Center,the PLA Clinical College of Anhui Medical University,Hefei 230031,China |
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| Abstract: | Mitogen activated protein kinase (MAPK),as a member of serine/threonine protein kinases,play important roles in the regulation of various life activities,including cell growth,development,differentiation and apoptosis after activation. Some components of MAPK pathway,such as cytokines of interleukin-6 (IL-6),fibroblast growth factor (FGF); protein kinase C (PKC),extracellular signal-regulated kinase (ERK),p38 and substrate of sperm tubulin,could directly or indirectly regulate the sperm motility. Studies on... |
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| Keywords: | Mitogen activated protein kinase Signal transduction Sperm motility Male infertility |
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