| 迷走神经及其递质在大鼠脑出血致多器官功能障碍综合征中的作用 |
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| 引用本文： | 王兴邦,娄建伟,麻琳,屈传强,李娜,郭洪志. 迷走神经及其递质在大鼠脑出血致多器官功能障碍综合征中的作用[J]. 临床神经病学杂志, 2009, 22(1) |
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| 作者姓名： | 王兴邦 娄建伟 麻琳 屈传强 李娜 郭洪志 |
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| 作者单位： | 山东大学齐鲁医院神经内科,济南,250012;复旦大学医学院生物医学研究院 |
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| 基金项目： | 山东省自然科学基金(Y2007C043) |
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| 摘 要： | 目的探讨迷走神经及其递质在大鼠脑出血(CH)致脑源性多器官功能障碍综合征(CMODS)中的作用。方法随机将80只Wistar大鼠分为假手术组(10只)、迷走神经切断(SDV)组(10只)、脑出血(CH)组(20只)、CH+SDV组(20只)和CH+迷走神经刺激(SIV)组(20只)。采用尾状核立体定向注射胶原酶和肝素钠制作CH大鼠模型,制模后出现肝功能、肾功能、心肌酶、血常规及生命体征异常达标的大鼠为CMODS模型。CH+SDV组大鼠在制模前4周行膈下SDV术;CH+SIV组大鼠在制模后行SIV,每次20min,每4h1次,共6次。各组大鼠于CH后24h行血常规、肝肾功能、心肌酶检查和主要脏器(肺、肝、肾、小肠)病理检查,用免疫组化法检测延髓内脏带(MVZ)内FOS蛋白、乙酰胆碱转移酶(CHAT)和血管活性肠肽(VIP)的表达,并与假手术组及SDV组比较。结果CH+SDV组、CH+SIV组和CH组的肝、肾功能,心肌酶异常程度以及肝、肾、小肠病理改变均重于假手术组和SDV组(均P<0.01);CH+SDV组又重于CH组(均P<0.01),而CH+SIV组明显轻于CH组(均P<0.05)。CH+SDV组的MVZ内...
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| 关 键 词： | 脑出血 脑源性多器官功能障碍综合征 迷走神经 递质 |
Effects of the vagus and its transmitter on multiple organ dysfunction syndrome induced by cerebral hemorrhage in rats |
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| WANG Xing-bang,LOU Jian-wei,MA Lin,et al.. Effects of the vagus and its transmitter on multiple organ dysfunction syndrome induced by cerebral hemorrhage in rats[J]. Journal of Clinical Neurology, 2009, 22(1) |
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| Authors: | WANG Xing-bang LOU Jian-wei MA Lin et al. |
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| Affiliation: | WANG Xing-bang,LOU Jian-wei,MA Lin,et al. Department of Neurology,Qilu Hospital,Sh,ong University,Jinan 250012,China |
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| Abstract: | Objective To explore the effects of the vagus and its transmitter on cerebrogenic multiple organ dysfunction syndrome induced by cerebral hemorrhage(CH) in rats. Methods 80 wistar rats were randomly divided into sham-operative group (n=10),subdiaphringmatic vagotomy (SDV) group (n=10),CH group (n=20), CH+SDV group (n=20) and CH+SIV group (n=20).Rat CH model was made by stereotaxis injection of collagenase and heparin sodium in caudate nucleus. The success full CMODS rat model was characterized by the abnorm... |
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| Keywords: | cerebral hemorrhage cerebrogenic multiple organ dysfunction syndrome vagus transmitter |
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