老年良性前列腺增生与体质指数及腰臀比关系

目的 探讨老年男性体质指数(BMI)、腰臀比(WHR)与临床良性前列腺增生(BPH)的关系.方法 采取以医院为基础的病例对照研究.病例组为经组织学检查证实为临床BPH的208例男性,对照组为因患其他非前列腺疾病而入住与病例相同医院的同期病人208例.对研究对象在住院期间进行问卷调查,同时对身高、体重、腰围、臀围进行测量.采用多元Logistic回归模型对患者BMI、WHR与临床BPH的比值比(OR)及其95%CI进行统计.结果 与正常体型者(WHR<0.9)相比,向心性肥胖者(WHR≥0.9)发生BPH的危险性增加,OR=1.16,95%CI=1.05~4.87,P<0.05.在调整了年龄和BMI因素后,与正常体型者相比,无论是超重(BMI 24.0~27.9)或是肥胖(BMI≥28),发生BPH的危险性均明显增高,超重者OR=2.65,95%CI=1.33~6.96,肥胖者OR=3.00,95%CI=1.81~8.84.结论 向心性肥胖是BPH的一个重要危险因素,在超重和肥胖的男性中,向心性肥胖者发生BPH的危脸性明显增高.

Body mass index,waist to hip ratio and the risk of benign prostatic hyperplasia in elderly

Objective To explore the association between body mass index(BMI),waist to hip ratio(WHR)and clinical benign prostatic hyperplasia(BPH)risk in older men.Methods A hospital-based case-control study was conducted.Cases(n=280)were men surgically and histologically confirmed with BPH,and controls(n=280)were men admitted to hospital for different diseases not related with prostatic conditions.Using a structured questionnaire,all subjects were interviewed and waist and hip circumference of the subjects were measured.The odds ratios(OR)and 95% confidence intervals(CI)of BPH for BM I and WHR were estimated with unconditional multiple logistic regression models.Results WHR≥0.9 was positively related to BPH(compared with WHR<0.9:O R=1.16,95% CI 1.05～4.87,P<0.05).Age-adjusted relative risks for BPH in WHR≥0.9 versus WHR<0.9 stratified by BM I(obesity)were estimated.For men who were overweight(BM I 24.0～27.9)or obesity(BM I≥28.0),WHR≥0.9 was associated with a significantly increased risk for clinical BPH(compared with WHR<0.9:OR=2.65,95% CI 1.33～6.96 and O R=3.00,95% CI=1.81～8.84,respectively).Conclusion Obesity(especially central obesity)is an important risk factor of clinical BPH.For overweight or obesity,central obesity is associated with a significantly increased risk of clinical BPH.