氨氯地平阿托伐他汀钙片对冠心病、高血压合并颈动脉粥样硬化患者的IMT、PV、TNF、CRP、血脂水平的影响

目的研究氨氯地平阿托伐他汀钙片对冠心病、高血压合并颈动脉粥样硬化患者的IMT、PV、TNF-α、CRP、血脂水平的影响。方法选取230例经颈动脉超声及冠脉造影检查证实有冠心病合并颈动脉粥样硬化患者作为研究对象,将所有患者分为对照组(未患有高脂血症,n=98)和研究组(患有高脂血症,n=132)。对照组患者给予氨氯地平片治疗,研究组患者给予氨氯地平阿托伐他汀钙片治疗,比较2组患者治疗前、治疗后3个月、治疗后6个月的血压水平、颈动脉IMT、PV、TNF-α、hs-CRP、HDL-C、LDL-C、TG、TC等血脂水平。结果 2组降压总有效率、不良反应发生率差异无统计学意义(P0.05)。2组治疗后3个月、6个月收缩压及舒张压、TNF-α、hs-CRP及血脂水平与治疗前比较差异均有统计学意义(P0.05)。研究组患者治疗后6个月颈动脉IMT与对照组及治疗前比较差异有统计学意义(P0.05)。2组患者治疗后3个月颈动脉PV与治疗前比较差异均有统计学意义(P0.05),2组治疗后6个月与治疗后3个月比较差异也有统计学意义(P0.05)。研究组治疗后3个月、治疗后6个月TNF-α、hs-CRP水平均明显低于对照组(P0.05)。结论氨氯地平阿托伐他汀钙片复方制剂具有稳定斑块、控制炎症、降脂、降压等功能,疗效肯定,且具有服用方便,依从性好,安全性好的优点。

Effect of amlodipine atorvastatin calcium tablet on IMT,PV, TNF,CRP, and blood lipid level of coronary heart disease and high blood pressure patients complicated with carotid atherosclerosis

Objective To study effect of amlodipine atorvastatin calcium tablet on IMT,PV,TNF,CRP,and blood lipid level of coronary heart disease and high blood pressure patients combined with carotid atherosclerosis.Methods A total of 230 patients with coronary heart disease (CHD) and carotid artery atherosclerosis confirmed by carotid artery ultrasonography and coronary angiography examination were selected as research objects,and were divided into control group (patients without hyperlipidemia,n =98) and study group (patients with hyperlipidemia,n =132).Control group was given amlodipine therapy,and the study group was treated with amlodipine atorvastatin calcium tablets.Blood pressure levels,carotid IMT,PV,TNF-α,hs-CRP,HDL-C,LDL-C,TG,TC of two groups were compared before and 3 months,6 months after treatment.Results The total effective rate and adverse reaction of two groups had no statistical difference (P ＞ 0.05).Systolic and diastolic blood pressure,TNF-α,hs-CRP and blood lipid level in the two groups at 3 months,6 months after treatment were statistically significant compared with the treatment before (P ＜ 0.05).Carotid artery IMT after 6 months of treatment in the study group showed significant difference compared with control group and treatment before (P ＜ 0.05).Carotid artery PV after 3 months of treatment in the two groups were statistically significant compared with treatment before (P ＜ 0.05),and it showed a statistically difference after 6 months of treatment compared with that of 3 months after treatment (P ＜ 0.05).TNF-α and hs-CRP levels in the study group after 3 months,6 months of treatment were significantly lower than the control group (P ＜ 0.05).Conclusion Amlodipine atorvastatin calcium tablets has the function of plaques stabilization,inflammation control,blood lipid and blood pressure decreasing,and it has better curative effect,and is characterized by good adherence and better security.