六君子汤加减对胃癌术后化疗减毒增免的临床效果观察

目的观察中药六君子汤加减治疗胃癌术后化疗不良反应临床疗效以及对免疫功能的影响。方法将64例住院患者分为实验组和对照组,每组32名,实验组进行六君子汤加减联合OLF方案化疗,对照组仅予OLF方案化疗,21天为1个疗程,2个周期后评价疗效,比较2组的不良反应、患者生活质量、免疫功能。结果对照组出现恶心呕吐、食欲下降、骨髓抑制程度的不良反应均较实验组严重(P0.05)。对照组化疗后的生活质量评分较前下降明显;2组治疗2个周期后,实验组的生活质量优于对照组(P0.05)。对于免疫功能,化疗治疗后,对照组患者的CD3~+、CD4~+、CD8~+、CD4~+/CD8~+、NK细胞活性均低于化疗前的水平;治疗2个周期后,实验组患者各项免疫功能指标显著优于对照组(P0.05)。结论六君子汤治疗胃癌术后化疗患者,可减轻不良反应,提高患者免疫力,改善患者生活质量。

Clinical observation of the add-substract liujunzi decoction on alleviating adverse reaction and enhancing immunity during postoperative chemotherapy for gastric cancer

Objective To observe the clinical effects of the add-substract liujunzi decoction on alleviating adverse reaction and improving immunity system during the postoperative chemotherapy for gastric cancer.Methods The 64 hospitalized patients were randomly divided into experiment group and control group,32 cases in each group.Both groups were given OLF regimen chemotherapy and the experiment group was given the extra add-substract liujunzi decoction.Twenty one days were considered as a treatment cycle.After two cycles,the curative effect was evaluated.The adverse reactions,quality of life and the immune function were compared.Results Compared with the experiment group,the control group showed more serious nausea and vomiting,the loss of appetite and bone marrow inhibition degree (P ＜ 0.05).The score of life quality in control group decreased significantly after chemotherapy.After two cycles,the life quality of the experiment group was significantly better than the control group (P ＜0.05).After the chemotherapy,the CD3 +,CD4 +,CD8 +,CD4 +/CDs + and NK cell activity of control group were significantly lower than those before treatment.After two cycles,all immune function indexes of the experimental group were better than those of the control group (P ＜ 0.05).Conclusion The add-substract liujunzi decoction for the postoperative gastric cancer patients can reduce the adverse reaction,improve the immune function and improve the quality of life.