RAD50,IL-33和IL1RL1基因与汉族人群过敏性哮喘发病的相关性

目的探讨CDHR3,GSDMB,IL-33,RAD50和IL1RL1等基因多态性位点与汉族人群过敏性哮喘及其严重程度的相关性。方法研究共纳入516例儿童过敏性哮喘患者和552例健康对照人群。对上述5个基因等多态性位点进行基因分型,包括CDHR3的rs6967330,GSDMB的rs2305480,IL-33的rs928413,RAD50的rs6871536和IL1RL1的rs1558641。比较患者组和对照组基因型和等位基因频率。分析基因型与临床表型包括FEV1%和总IgE的关系。结果与对照组相比,患者组有显著较高频率的rs928413等位基因G和rs6871536等位基因C(P0.001)。患者组较正常对照组有显著降低的rs1558641等位基因G(P=0.007)。相比与其他基因型,患者rs928413基因型GG和rs1558641基因型GG与低FEV1%和高水平的血清总IgE有显著相关性。结论 IL-33,IL1R1和RAD50基因与中国人群的哮喘风险相关。

Correlation between polymorphisms of RAD50, IL-33 and IL1 RL1 and allergic asthma in Han population

Objective To investigate correlation between genetic polymorphisms of CDHR3 (rs6967330),GSDMB (rs2305480),IL-33 (rs928413),RAD50 (rs6871536) and IL1RL1 (rs1558641) and occurrence and severity of allergic asthma in Han population.Methods Genotype and allele frequencies were compared between 516 patients and 552 controls by Chi-square test.Correlation between genotype and FEV1,total IgE was analyzed.Results Compared with the controls,the allergic patients had significantly higher allergic G of rs928413 and allergic C of rs6871536 (P ＜0.001).Besides,allergic patients were found to have significantly lower frequency of allergic A of rs1558641 (P =0.007).Compared with other genotypes,patients with rs928413 genotype GG and rs1558641 genotype GG were significantly correlated with low FEV1％ and high level of serum total IgE.Conclusion Gene IL-33,IL1R1,and RAD50 are correlated with the risk of asthma in Han population.