云南红河哈尼族ABO、Rh血型分布规律及基因频率调查

目的了解云南红河哈尼族无偿献血人群ABO及Rh血型分布规律以及基因频率。方法采用血站ABO血型正反2次定型及Rh(D)筛查及鉴定程序,对云南红河哈尼族6 817例无偿献血人群进行血型鉴定。结果云南红河哈尼族A型、B型、O型及AB型构成比分别为25.08%、27.92%、39.81%及7.19%;期望值构成比为25.19%、28.08%、40.02%及6.73%,基因频率P=0.1749,q=0.1925,r=0.6326,观察值与期望值无显著差异(P0.05),分布符合Hardy-Weinberg平衡。ABO血型分布为O型B型A型AB型。6 817例云南红河哈尼族共检出Rh D(-)23例,占0.37%,其中CCdee为21.74%,Ccdee为47.83%,ccdee为30.43%,其期望值构成比为20.87%、49.57%及29.57%,基因频率Cde为0.4566,cde为0.5434,观察值与期望值无显著差异(P0.05),分布符合Hardy-Weinberg平衡。结论对哈尼族无偿献血人群ABO及Rh血型分布规律以及基因频率的研究对本地区采供血计划的制定及安全用血均有重要的指导意义。

Investigation on ABO and Rh blood group distribution and gene frequency of Honghe Hani nationality in Yunnan

Objective To explore the distribution of ABO and Rh blood group and the gene frequency of the voluntary blood donors in Honghe Hani autonomous prefecture of Yunnan province.Methods The blood group identification of 6 817 cases of voluntary blood donators in Honghe Hani nationality in Yunnan was carried out by the positive and negative ABO and Rh (D) screening and identification procedures.Results In Yunnan Honghe Hani people,type A,type B,type O and type AB accounted for 25.08%,27.92%,39.81% and 7.19% respectively,the expected value of the ratio was 25.19%,28.08%,40.02% and 6.73% respectively,the gene frequency of P was 0.1749,Q was 0.1925,r=0.6326,and there was no significant difference between the observation value and the expected value (P>0.05).Distribution was correlated with the Hardy-Weinberg equilibrium,and the distribution of ABO type was type O >type B >type A >type AB.In 6 817 Yunnan Honghe Hani people,RhD (-) were detected in 23 cases,accounted for 0.37%,including CCdee was 21.74%,Ccdee was 47.83%,ccdee was 30.43%,the expected value of the ratio was 20.87%,49.57% and 29.57%,the frequency of Cde gene was 0.4566,CDE was 0.5434,and there was no significant difference betweeen the observed and expected value (P>0.05).Distribution was correlated with the Hardy-Weinberg equilibrium.Conclusion The study on the distribution of ABO and Rh blood group and the gene frequency of the non remunerated blood donors of Hani nationality have important guiding significance for the establishment of blood collection and blood supply plan and the safety of blood.