CYP17A1基因多态性与原发性高血压的相关性研究

目的探讨CYP17A1基因rs11191548位点多态性与原发性高血压关系。方法选取原发性高血压患者143例和健康体检者199例。应用Taq Man探针分析CYP17A1基因rs11191548位点多态性的基因型,并探讨其相关性,采用逐步Logistic回归分析,分析获得性因素对高血压的影响。结果经χ~2检验,2组间基因型分布差异有统计学意义(P0.05),2组间等位基因频率分布差异有统计学意义(P0.05)。TT和CT基因型较CC基因型对于患病具有较高风险,CC基因型的个体患高血压的风险分别是携带TT基因型的0.370倍,携带T等位基因的个体患高血压的风险是携带C等位基因的1.776倍。获得性因素中,空腹血糖、甘油三酯及年龄较高的人群具有更高的患病风险。结论 CYP17A1基因rs11191548多态性与原发性高血压发病可能相关,其中TT基因型及T等位基因的个体患高血压的风险升高,获得性因素对高血压的发病有显著影响。

Association between CYP17A1 gene polymorphism and essential hypertension

Objective To investigate the relationship between rs11191548 gene locus polymorphism in CYP17A1 gene and essential hypertension.Methods A total of 143 patients with essential hypertension and 199 healthy subjects were selected.TaqMan probe was used to analyze the genotype of rs11191548 gene locus in CYP17A1 gene and their correlation was analyzed.Stepwise Logistic regression analysis was used to analyze the influence of acquired factors on hypertension.Results There was significant difference in genotype distribution and allele frequency distribution between the two groups(P<0.05).TT and CT genotype had higher risk for diseases compared with CC genotype,the CC genotype of the risk of hypertension was 0.370 times with the TT genotype,and individuals carrying the T allele were 1.776 times the risk of hypertension with C allele.Fasting blood glucose,triglycerides,and older people were more likely to have a higher risk of hypertension.Conclusion The rs11191548 polymorphism of CYP17A1 gene may be associated with the pathogenesis of essential hypertension,and the individuals with TT genotype and T allele may be at increased risk of developing hypertension.Acquired factors have a significant impact on the incidence of hypertension.