呋喃唑酮与替硝唑分别联合奥美拉唑、左氧氟沙星三联对老年Hp阳性慢性萎缩性胃炎幽门螺旋杆菌根除率的比较研究

目的比较呋喃唑酮与替硝唑分别联合奥美拉唑、左氧氟三联对老年HP阳性慢性萎缩性胃炎幽门螺旋杆菌根除率。方法选取Hp阳性慢性萎缩性胃炎老年患者96例,按随机数字表法分为2组各48例。对照组予以替硝唑+奥美拉唑+左氧氟沙星三联方案,研究组予以呋喃唑酮+奥美拉唑+左氧氟沙星三联方案。采血测定胃功能、炎症因子及免疫功能指标,同时比较临床疗效及Hp根除率。结果 2组治疗后症状学积分和病理学积分显著降低,G-17、PG-Ⅰ含量显著升高,PG-Ⅱ含量显著降低,血清IL-6、TNF-α、s IL-2R含量显著降低,CD_4+、CD_4~+/CD_8~+含量升高,CD8+含量显著降低(P0.05)。2组治疗后上述指标比较有显著差异(P0.05)。对照组有效率、Hp转阴率显著低于研究组(P0.05)。结论呋喃唑酮联合奥美拉唑、左氧氟三联方案能提高Hp阳性慢性萎缩性胃炎Hp根除率和临床疗效。

Furazolidone combined with omeprazole and levofloxacin versus tinidazole combined with omeprazole and levofloxacin in eradication rate of helicobacter pylori in elderly patients with Hp positive chronic atrophic gastritis

Objective To compare the eradication rate of helicobacter pylori between furazolidone combined with omeprazole and levofloxacin and tinidazole combined with omeprazole and levofloxacin in elderly patients with Hp positive chronic atrophic gastritis.Methods A total of 96 patients with Hp positive chronic atrophic gastritis were randomly divided into two groups,48 cases in each group.Control group was treated with tinidazole plus omeprazole and levofloxacin,while study group was treated with furazolidone plus with omeprazole and levofloxacin.The gastric function,inflammatory factors and immune function indexes were measured,and the clinical efficacy and the eradication rate of Hp were compared.Results After treatment,symptoms and pathological scores significantly decreased in both groups,G-17,PG-I contents increased significantly,PG-II content decreased significantly,serum IL-6,TNF-α,sIL-2R contents decreased significantly,CD4+ and CD4+/CD8+ contents increased significantly,and CD8+ content decreased significantly(P<0.05).There were significant differences in indexes mentioned above between the two groups(P<0.05).The effective rate and negative rate of Hp in the control group were significantly lower than those in the study group(P<0.05).Conclusion Furazolidone combined with omeprazole and levofloxacin