PLCE1和RFT2表达与食管鳞状细胞癌的相关性及对预后的影响

目的分析PLCE1和RFT2表达与食管鳞状细胞癌的相关性及对预后的影响。方法选取90例食管癌患者,采用免疫组化SP法检测食管鳞状细胞癌组织中和癌旁正常食管组织中PLCE1和RFT2的表达,分析PLCE1和RFT2在食管鳞状细胞组织及正常食管组织中的表达、PLCE1和RFT2的表达与临床病理特征的关系以及PLCE1和RFT2的表达相关性。结果PLCE1和RFT2在食管鳞状细胞组织及正常食管组织中的阳性率分别为86.67%、16.00%及80.00%、18.00%,差异有统计学意义(P0.05);PLCE1和RFT2表达与食管癌临床T分期、淋巴结转移及肿瘤最长径相关(P0.05);食管癌组织中的PLCE1与RFT2表达呈明显正相关(rs=6.544 8,P0.05)。结论 PLCE1和RFT2在食管鳞状细胞癌中呈高表达,且与肿瘤最长径、淋巴结转移及临床分期关系密切。

Correlation between PLCE1, RFT2 expressions and esophageal squamous cell carcinoma and their effects on prognosis

Objective To analyze the correlation between PLCE1,RFT2 expressions and esophageal squamous cell carcinoma and their effects on prognosis.Methods Ninety esophageal cancer patients were selected.Immunohistochemical SP method was used to detect PLCE1 and RFT2 expressions in esophageal squamous cell carcinoma and adjacent normal esophageal tissues,and correlation between PLCE1,RFT2 expressions and clinicopathological features as well as relationship between PLCE1 and RFT2 were analyzed.Results Positive rates of PLCE1 and RFT2 in esophageal squamous cell tissue and normal esophageal tissues were 86.67％,16.00％ and 80.00％,18.00％ respectively,and there were significant differences (P ＜ 0.05).PLCE1 and RFT2 expressions were correlated with esophageal clinical T stage,lymph node metastasis and the longest diameter (P ＜ 0.05).PLCE1 expression was positively correlated with RFT2 expression in esophageal cancer tissue (rs =6.544 8,P ＜ 0.05).Conclusion PLCE1 and RFT2 are highly expressed in esophageal squamous cell carcinoma,and are closely correlated with tumor maximum diameter,lymph node metastasis and clinical stages.