化疗对晚期肺癌患者肿瘤标志物水平变化的影响

目的观察化疗对晚期肺癌患者血清肿瘤标志物水平变化的影响。方法选取晚期肺癌患者75例,所有患者均接受含铂类两药联合的化疗方法,根据影像学中实体瘤的变化评定化疗疗效,采用免疫化学发光法检测患者治疗前及化疗4个疗程后血清各肿瘤标志物(血清中癌胚抗原,神经元特异性烯醇化酶,糖类抗原125,细胞角蛋白Ig的可溶性片段CYFRA211,鳞状上皮细胞癌抗原等)的水平。结果化疗后患者各血清肿瘤标志物水平均显著低于化疗前(P0.05)。完全缓解和部分缓解患者血清肿瘤标志物水平的降低水平显著高于疾病加重患者(P0.05)。不同类型晚期肺癌患者化疗前后的血清标志物水平也存在差异。结论有效的化疗可以显著降低晚期肺癌患者血清肿瘤学标志物的水平。

Influence of chemotherapy on the changes of tumor markers levels in patients with advanced lung cancer

Objective To observe the influence of chemotherapy on the changes of tumor markers levels in patients with advanced lung cancer.Methods A total of 75 patients with advanced lung cancer were selected amd treated with the combination of two drugs based on platinum.The therapeutic effect was judged by the changes of solid tumor according to medical image.The levels of tumor markers before and after the treatment were tested by chemiluminescence immunoassay,and tumor markers including cancer embryonic antigen(CEA),neuron specific enolase(NSE),carbohydrate antigen 125(CA125),cytokeratin(CYFRA211),squamous cell cancer antigen(SCC).Results The levels of tumor markers were significantly lower after the treatment than those before the treatment(P<0.05).The decreased level of patients with CR and PR were significantly lower than those with SD and PD(P<0.05).There was significant difference in the changes of tumor markers levels before and after treatment between the patients with different tumor types.Conclusion Effective chemotherapy can significantly decrease the levels of tumor markers in patients with advanced lung cancer.