术前应用醋酸亮丙瑞林对腹腔镜下子宫肌瘤剔除患者激素水平、月经及子宫肌瘤复发的影响

目的探讨腹腔镜下子宫肌瘤剔除术前应用醋酸亮丙瑞林对患者激素水平、月经及子宫肌瘤复发的影响。方法选取子宫肌瘤患者100例,随机分为实验组和对照组。对照组进行腹腔镜下子宫肌瘤剔除术。实验组术前给予醋酸亮丙瑞林,再进行腹腔镜下子宫肌瘤剔除术。观察患者的血清激素水平、月经情况、肌瘤体积及子宫肌瘤复发等情况。结果实验组患者使用醋酸亮丙瑞林后,黄体生成素、卵泡刺激素、血清雌二醇含量均显著低于用药前,月经量、子宫体积、肌瘤体积显著小于用药前。实验组患者的术中出血量、盆腔引流量、下床活动时间、住院时间显著优于对照组(P0.05)。结论腹腔镜下子宫肌瘤剔除术前应用醋酸亮丙瑞林的临床疗效和安全性均较好,可显著降低患者的血清激素水平,改善月经量。

Effect of preoperative application of leuprorelin acetate on hormone levels,menstrual and uterine fibroids recurrence in patients with laparoscopic myomectomy

Objective To investigate the effect of preoperative application of leuprolide acetate on hormone levels,menstrual and uterine fibroids recurrence in patients with laparoscopic myomectomy.Methods A total of 100 patients with hysteromyoma were randomly divided into experimental group (n=50) and control group (n=50).The control group was treated with laparoscopic myomectomy,while the experimental group was treated with leuprorelin acetate before laparoscopic myomectomy.The levels of serum hormones,menstruation,fibroid volume and recurrence rate of uterine fibroids were observed.Results In the experimental group,after use of leuprolide acetate,the luteinizing hormone,follicle stimulating hormone and serum estradiol were significantly lower than those before treatment,and menstrual blood volume,uterine volume,leiomyoma volume were significantly less than those before treatment (P<0.05).Compared with the control group,the amount of bleeding in operation and pelvic drainage were significantly lower,and ambulation time,hospitalization time were significantly shorter in experimental group (P<0.05).Conclusion Before the laparoscopic myomectomy,the clinical efficacy and safety of leuprolide acetate is great,which can reduce the serum hormone level,improve the volume of leiomyoma.