急性冠脉综合征急性期他汀类药物治疗方案及剂量选择的临床研究

目的探讨急性冠脉综合征急性期他汀类药物治疗方案及剂量选择。方法选择120例急性冠脉综合征急性期患者,通过随机数表法分为3组,即A组(阿托伐他汀20 mg),B组(阿托伐他汀10 mg),C组(常规治疗)。比较3组治疗效果。结果治疗后,A组、B组总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-L)、超敏C反应蛋白(hs-CRP)水平均显著改善(P0.05);在治疗后4周、8周时,A组TC、TG、LDL-C水平均比其他2组低(P0.05),hs-CRP水平均低于其他2组(P0.05),TC、LDL-C达标率均优于其他2组(P0.05);A、B组阿托伐他汀治疗患者不良反应发生率无显著差异(P0.05);通过对所有患者8个月的随访,A组患者心血管事件发生率显著低于其他2组(P0.05)。结论在急性冠脉综合征急性期患者中,早期使用大剂量的阿托伐他汀效果显著,可达到有效的抗炎、降脂作用,降低心血管事件发生率。

Clinical study on statin therapy and dose selection in treatment of patients with acute coronary syndrome in acute stage

Objective To explore the statin therapy and dose selection in treatment of patients with acute coronary syndrome in acute stage.Methods A total of 120 patients with acute coronary syndrome in acute stage were selected and randomly divided into the group A (atorvastatin 20 mg),group B (atorvastatin 10 mg) and group C (routine treatment).The effect was compared.Results After treatment,the levels of total cholesterol (TC),triglyceride (TG),low density lipoprotein cholesterol (LDL-L),and high sensitive C reactive protein (hs-CRP) significantly improved in the group A and group B (P ＜ 0.05).After 4 weeks and 8 weeks of treatment,the levels of TC,TG,LDL-C in group A were significantly lower than the other two groups (P ＜ 0.05),the hs-CRP was significantly lower than the other two groups (P ＜ 0.05),and the TC,LDL-C standard rate were significantly better than the other two groups (P ＜ 0.05).There was no significant difference in the incidence rate of adverse reactions between the group A and group B.After 8 months of follow up,the incidence rate of cardiovascular events in group A was significantly lower than the other two groups (P ＜ 0.05).Conclusion Early use of large doses of atorvastatin is effective in treatment of patients with acute coronary syndrome in acute stage,and it can achieve the anti-inflammatory and lipid lowering effects,and reduce the incidence rate of cardiovascular events.