黄芪注射液对急性淋巴细胞白血病患儿诱导缓解化疗期间感染的影响

目的分析黄芪注射液对急性淋巴细胞白血病(ALL)患儿诱导缓解化疗期间感染的影响。方法选取ALL患儿100例,将其随机分为观察组和对照组各50例,2组患儿均应用诱导缓解化疗方案治疗,观察组患儿同时加用黄芪注射液静脉滴注,对2组患儿化疗期间的医院感染发生率、发生部位及化疗前、后外周血白细胞(WBC)和中性粒细胞(NE)计数进行观察和比较。结果观察组患儿化疗期间感染的总发生率显著低于对照组,观察组中各危险度分型患儿的感染发生率亦显著低于对照组中的同种分型患儿(χ~2=13.000、4.250、3.895、5.106,P0.05),观察组患儿化疗期间呼吸道、泌尿道、皮肤软组织感染的发生率显著高于对照组(χ~2=11.602、4.960、6.112,P0.05),化疗后观察组中各危险度分型患儿的外周血NE计数均显著高于对照组中的同种分型患儿(t=5.265、3.795、4.286,P0.05)。结论在ALL患儿的诱导缓解化疗期间,加用黄芪注射液能够缓解患儿的骨髓抑制,降低ALL患儿的感染发生率。

Effect of astragalus injection on the infection of children with acute lymphoblastic leukemia in induction remission chemotherapy

Objective To analyze the effects of astragalus injection on the infection of children with acute lymphoblastic leukemia (ALL) in induction remission chemotherapy.Methods A total of 100 ALL patients were randomly divided into observation group and control group,50 cases in each gToup.Both groups were treated with induction remission chemotherapy,and the children in the observation group were treated with additional intravenous drip of astragalus injection.The incidence rate and the sites of the nosocomial infections during induction remission chemotherapy as well as the white blood cell (WBC) counting,the neutrophil (NE) counting in the peripheral blood before and after the chemotherapy were observed and compared in both groups.Results The overall incidence rate of infections in the observation group during the chemotherapy was significantly lower than that in the control group,and the incidence rates of infections of the children with various subtype of risk degree in the observation group during the chemotherapy were significantly lower than those of the children with the same subtype of risk degree in the control group (x2 =13.000,4.250,3.895,5.106,P ＜ 0.05).The incidence rate of infections such as respiratory tract,urinary tract,skin and soft tissue during the chemotherapy in the observation group was significantly higher than that in the control group (x2 =11.602,4.960,6.112,P ＜0.05).After the chemotherapy,the NE counting in peripheral blood of the patients with various subtype of risk degree in the observation group was significantly higher than that of the patients with same subtype of risk degree in the control group (t =5.265,3.795,4.286,P ＜ 0.05).Conclusion In ALL children with induction remission chemotherapy,the application of astragalus injection can alleviate the bone marrow suppression and reduce the incidence rate of infection.