| 青海土族人群HLA-DRB1等位基因多态性分析 |
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| 引用本文： | 曹海霞,徐昕,洪军,王靖.青海土族人群HLA-DRB1等位基因多态性分析[J].中国免疫学杂志,2008,24(11). |
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| 作者姓名： | 曹海霞 徐昕 洪军 王靖 |
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| 作者单位： | 青海省妇女儿童医院,西宁,810007 |
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| 基金项目： | 青海省卫生厅青年科学研究基金
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| 摘 要： | 目的：分析青海土族人群HLA-DRB1位点等位基因多态性特点。方法：采用序列特异性引物聚合酶链反应技术,对青海互助地区50名健康无血缘关系的土族个体HLA-DRB1基因座进行分型,并与国内其他地区少数民族人群进行比较。结果：青海土族人群中HLA-DRB基因座共检出16个等位基因,其中DRB1＊04、DRB1＊08、DRB1＊14、DRB1＊15、DRB3＊、DRB4＊基因频率较高；DRB1＊06、DRB1＊07、DRB1＊09、DRB1＊13、DRB1＊16、DRB1＊23基因频率较低。结论：青海土族HLA有独特性。青海土族基因频率与蒙古族有相似之处。
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| 关 键 词： | 青海土族 人类白细胞抗原 HLA-DRB1 多态性 |
The analysis of HLA-DRB1 allelic polymorphism in Tu race population of Qinghai region of China |
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| CAO Hai-Xia,XU Xin,HONG Jun,WANG Jing.The analysis of HLA-DRB1 allelic polymorphism in Tu race population of Qinghai region of China[J].Chinese Journal of Immunology,2008,24(11). |
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| Authors: | CAO Hai-Xia XU Xin HONG Jun WANG Jing |
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| Institution: | CAO Hai-Xia,XU Xin,HONG Jun,WANG Jing.Qinghai Maternity , Children Hospital,Xining 810007,China |
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| Abstract: | Objective:To investigate the HLA-DRB1 allele polymorphism of the Tu race population in Qinghai region of China.Methods:Polymerase chain reaction and hybridizations of sequence-specific olignucleotide probe was used to detect HLA-DRB1 alleles in 50 unrelated healthy Tu individuals from Qinghai region,and the results were compared with those of minority populations in China.Results:Sixteen of alleles were detected and identified for HLA-DRB.HLA-DRB11*04,DRB1*08,DRB1*14,DRB1*15,DRB3*,DRB4* were the most common... |
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| Keywords: | HLA-DRB1 |
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