Ki-67、p53在脑胶质瘤中的表达及意义

目的探讨Ki-67和p53与脑胶质瘤分级的关系。方法采用免疫组化SP法检测60例脑胶质瘤标本和10例正常脑组织标本Ki-67和p53的表达。结果 Ki-67和p53在正常脑组织与脑胶质瘤中的表达差异均有统计学意义（Ki-67：χ2=13.081,P=0.004;p53：χ2=11.667,P=0.009）;Ⅰ～Ⅱ级胶质细胞瘤与高度恶性Ⅲ～Ⅳ级胶质细胞瘤Ki-67和p53的表达差异均有统计学意义（Ki-67：χ2=12.589,P=0.006;p53：χ2=12.721,P=0.005）。结论脑胶质瘤中Ki-67及p53的阳性表达率与其恶性度相关,均可作为判断胶质瘤恶性程度的指标。

Expression of p53 and Ki-67 in the Gliomas and its Clinical Significance

Objective To determine the relationship between the expressions of Ki-67 and p53 and the grading of the gliomas.Methods The expressions of Ki-67 and p53 in 60 samples of human gliomas and 10 normal tissue specimens were detected by the immunohistochemistry method（SP）.Results There＇s significant diference in the expression of T Ki-67 and p53 between normal brain tissue and glioma（Ki-67：χ2=13.081,P=0.004;p53：χ2=11.667,P=0.009）.Significant difference exist between gradeⅠ~Ⅱglioma and grade Ⅲ~Ⅳ glioma（Ki-67：χ2=12.589,P=0.006;p53：χ2=12.721,P=0.005）.Conclusion Ki-67 and p53 express in high percentage of gliomas.The expressions of Ki-67 and p53 in gliomas may be used as tumor markers evaluating the histograde of human glioma.