不同程度慢性乙型肝炎患者血氨浓度比较及幽门螺杆菌感染对血氨的影响

目的观察不同程度慢性乙型肝炎患者的血氨浓度及幽门螺杆菌(Hp)感染对血氨浓度的影响.方法对420例慢性乙肝病人采用14C呼气试验检测Hp感染,用谷氨酸脱氢酶两点法测定病人的血氨浓度,同时对随机选取的70例Hp阳性乙肝患者进行抗Hp治疗.结果血氨浓度重度肝炎组(87.0±14.7)μmol/L]高于轻度(59.0±18.9)μmol/L]和中度(62.0±20.1)μmol/L]肝炎组(均P＜0.05).血氨浓度轻度、中度、重度肝炎组病人中Hp感染者(56.0±14.7)μmol/L、(58.0±17.9)μmol/L、(87.0±14.7)μmol/L]与非感染者(55.0±14.7)μmo1/L、(60.0±15.5)μmol/L、(86.0±20.1)μmol/L]的差别均无显著性意义(均P＞0.05).伴Hp感染的乙肝病人抗Hp治疗前血氨浓度(59.0±15.4)μmol/L]与治疗后血氨浓度(64.0±21.5)μmol/L]的差别也无显著性意义(P＞0.05).结论乙肝患者的血氨浓度与是否存在Hp感染无关,而与肝炎的严重程度有关.

Serum ammonia levels in patients with chronic hepatitis B and their relation with Helicobacter pylori infection

Objective To compare the concentrations of the serum ammonia among patients with chron-ic hepatitis B of different severity and to observe their relation with Helicobacter pylori(Hp)infection.Methods Hp were detected by the 14 C breath test in420patients with chronic hepatitis B,and the concentration of the serum ammonia were detected by Glutamic dehydrogenase test.Among all Hp( )patients,70were received anti-Hp therapy.Results The concentrations of serum ammonia in the severe hepatitis B group were higher than those in mild group(P<0.05)and moderate group(P<0.05).There was no significant difference between the concentrations of serum ammonia in the Hp ( )patients and the Hp (-)patients(P>0.05).After the anti-Hp therapy no significant changes in serum ammonia concentration were found(P>0.05).Conclusion The concentrations of the serum ammonia in hepatitis B patients are correlated with the severity of disease and not correlated with co-infection with Helicobacter pylori.