Analysis of resveratrol as a lung cancer chemopreventive agent in A/J mice exposed to benzo[a]pyrene |
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Authors: | Berge G Øvrebø S Eilertsen E Haugen A Mollerup S |
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Institution: | Department of Toxicology, National Institute of Occupational Health, PO Box 8149 Dep, N-0033 Oslo, Norway. |
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Abstract: | Resveratrol inhibits PAH bioactivation through reduced expression of the CYP1A1 and CYP1B1 genes in human bronchial epithelial cells. Ad libitum access to a diet containing resveratrol showed no effect on benzoa]pyrene-induced lung tumorigenesis in A/J mice. Also, resveratrol did not change CYP1A1 and CYP1B1 gene expression or benzoa]pyrene protein adduct levels in the lung tissue. The lack of chemopreventive activity may have been caused by insufficient concentrations or nonreactive forms of resveratrol in the lungs. |
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Keywords: | lung carcinogenesis benzo[a]pyrene resveratrol adducts CYP1A1 CYP1B1 |
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