透明质酸介导的细胞游走受体基因的分子生物学特性及其与肿瘤的关系

透明质酸介导的细胞游走受体(receptor for hyaluronan-mediated motility,RHAMM)是继CD44之后发现的,分布于细胞膜表面、细胞浆以及细胞核,参与细胞分裂周期的调节、细胞的生长增殖、细胞迁移运动、细胞骨架的组装以及维持中心体和纺锤体极的结构的完整性,与细胞恶性转化、肿瘤浸润和转移等生物学行为密切相关;并且已作为一些肿瘤的肿瘤相关抗原,确定了其抗原表位,成为肿瘤免疫治疗的靶点;在一些肿瘤组织内的表达水平升高和呈现一定的表达模式,与肿瘤临床分级以及肿瘤预后有一定的相关性。

Molecular Biology of RHAMM and Its Relationship with Cancer

RHAMM, a receptor for hyaluronan-mediated motility, is the second receptor for hyaluronan identified after CD44 and it is expressed on cell surface and in the cytoplasm, as well as in nucleus. It participates in the regulation of cell division cycle, cell growth, cell migration, assembly of cytoskeleton and the maintenance of pole stability of spindle and structural integrity of centrosome. Its expression has been linked to cell transformation, tumor progression and metastasis. Moreover, RHAMM has been considered to be a tumor-associated antigen and has become a new target for tumor immunotherapy. Moreover, the overexpression and specific expression pattern of RHAMM are associated with clinical grade and poor prognosis of cancer.