输血传播病毒(TTV)感染的慢性肝病临床研究

目的：研究慢性肝病输血传播病毒（TTV）感染的临床意义和TTV的致病性。方法：采用TTV套式PCR（聚合酶链式反应）检测183例慢性肝病的TTV感染，分析其肝功生化结果。结果：慢性乙型肝炎（CHB）患TTVDNA阳性48例，其中并有肝硬化12例，占25％（12／48）；重型肝炎18例，占37．5％（18／48）。病死12例，病死率为25％（12／48）；TTVDNA阴性90例，其中肝硬化6例，占6．7％（6／90），重型肝炎6例，占6．7％（6／90），病死3例，病死率3．3％（3／90）。非甲非乙型慢性肝炎有18例TTVDNA阳性，其中TTV阳性的病例无一例并发肝硬化和重型肝炎。HBV＋TTV混合感染的慢性肝炎组的总胆红质和ALT水平均高于CHB组和单纯TTV感染的慢性肝炎组，白蛋白和PTA水平均低于后两组，有显性差异。结论：TTV套式PCR是检测TTV感染的可靠手段之一。HBV和TTV混合感染可以加重病情，容易并发肝炎后肝硬化和形成重型肝炎，病死率高。

Clinical analysis of chronic hepatitis complicated with transfusion-transmitted virus

Objective:To study the significance of chronic hepatitis complicated by transfusion-transmitted virus(TTV),as well as the pathogenicity of TTV.Methods:185 cases of chronic hepatitis were detected by nested PCR technology,the results of biochemical assay of hepatc function were analyzed.Results:Out of 138 cases of chronic hepatitis B,TTV DNA were detected in 48 cases,among them,there were 12 cases of cirrhosis(25%),18 cases of severe hepatitis(37 5%),12 cases died(25%);90 cases showed negative in the detection of TTV DNA,there were 6 cases of cirrhosis(6 7%),6 cases of severe hepatitis(6 7%),3 cases died(3 3%).Out of 47 cases of non-A-G hepatitis,TTV DNA were detected in 18 cases,but no case supervened with cirrhosis and severe hepatitis.STB and ALT were higher in HBV+TTV group than that in TTV-negative group and that in simple TTV group(P<0 05),albumin and PTA were lower in HBV+TTV group than that in TTV-negative group and that in simple TTV group (P<0 01).Conclusion:TTV can be detected effectively by nested PCR technology.The patients were in a bad way due to affection of HBV and TTV,and the patients supervened with cirrhosis and severe hepatitis,the fatality rate was high.