Effects of postnatal aluminum exposure on biological parameters in the rat plasma |
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| Institution: | 1. Centre des Sciences de l''Environnement (Neurotoxicologie), Université de Metz, 1 rue des Récollets, B.P. 4025, 57040 Metz Cedex 1. France;2. Laboratoire de Biochimie, CHR de Metz-Thionville, Thionville, France;3. Service de Chimie Générale appliquée á la Médecine, Faculté de Médecine, Université de Nancy 1, Nancy, France;4. Laboratoire de Biologie du Comportement, Faculté des Sciences, Université de Nancy 1, Nancy, France;1. The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China;2. Hepatobiliary Pancreatic Tumor Center, Chongqing University Cancer Hospital, Chongqing 400030, China;1. The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) & Key Laboratory of Oral Biomedicine Ministry of Education, School & Hospital of Stomatology, Wuhan University, People’s Republic of China;2. Department of Bioengineering, Rice University, Houston, TX, USA;1. Department of Animal Sciences, Purdue University, West Lafayette, IN 47907, United States;2. Division of Animal Sciences, University of Missouri, Columbia, MO 65221, United States;1. Hydro-Quebec Research Center (IREQ), 1800 boul. Lionel-Boulet, Varennes, Qc J3X 1S1, Canada;2. Environmental Molecular Sciences Laboratory (EMSL), Pacific Northwest National Laboratory (PNNL), 902 Battelle Boulevard, P.O. Box 999, MSIN K8-93, Richland, WA 99352, USA;3. Department of Mechanical Engineering and Materials Science, University of Pittsburgh, 3700 O''Hara Street, Pittsburgh, PA 15261, USA;4. Université du Québec à Montréal (UQÀM), Case postale 8888, succursale Centre-ville, Montréal, Qc H3C 3P8, Canada;1. State Key Laboratory of Tea Plant Biology and Utilization, School of Tea and Food Science & Technology, Anhui Agricultural University, Hefei, Anhui 230036, PR China;2. International Joint Laboratory on Tea Chemistry and Health Effects, Anhui Agricultural University, Hefei, Anhui 230036, PR China;3. Department of Clinical Nutrition, Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu 212000, PR China;4. Pritzker School of Medicine, University of Chicago, Chicago, IL 60637, USA;5. Department of Food Science, Rutgers University, New Brunswick, NJ 08901, USA |
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| Abstract: | Young rats were treated by gastric intubation with aluminum chloride (100 mg Al/kg/day) and aluminum lactate (100 and 200 mg Al/kg/day) from postnatal days 5 to 14. This treatment lead to a reduction in body weight. The plasma concentrations of total proteins and albumin decreased whereas the α1 globulins increased in the treated rats. The aluminum concentrations in plasma and hepatic homogenates increased particularly at 200 mg Al lactate. The reduction in average body weight could be attributed to various causes: a decreased food consumption, a transient undernutrition, a reduction of the protein synthesis in the liver. The increase of the plasma concentration of the α1 globulins revealed an inflammation process. |
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