Chronic manipulation of dietary salt modulates renal physiology and kidney dopamine receptor subtypes: Functional and autoradiographic studies |
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| Institution: | 1. Gansu Provincial Key Laboratory of Arid land Crop Science, Lanzhou 730070, China;2. College of Agronomy, Gansu Agricultural University, Lanzhou 730070, China;1. University of Lyon, University Claude Bernard Lyon-1, CNRS, LAGEP UMR 5007, 43 boulevard du 11 novembre 1918, F-69100, Villeurbanne, France;2. Lebanese University, Faculty of Sciences, B.P 906564, Jdaidet El-Matn, Lebanon;3. Kabul University, Faculty of Pharmacy, Kabul, Afghanistan;4. Universidad Autónoma de Nuevo León, Facultad de Ciencias Biológicas, Laboratorio de Química Analítica, Av. Pedro de Alba s/n, C.P. 66455, San Nicolás de los Garza, Nuevo León, Mexico;1. School of Pharmaceutical Science, Jiangnan University, 1800 Lihu Road, Wuxi 214122, People''s Republic of China;2. Department of Pharmaceutics Science, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang 110016, People''s Republic of China;3. Jiangsu Simcere Pharmaceutical Co. Ltd, 699-18 Xuanwu Avenue, Nanjing 210042, People''s Republic of China |
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| Abstract: | - 1.1. Compared to rats maintained on the normal NaCI (0.33%) diet, animals maintained on the low NaCl (0%) diet for 4 weeks exhibited increased plasma aldosterone and chloride and decreased urinary sodium excretion.
- 2.2. Rats maintained on the high NaCl (8%) diet for 4 weeks showed increased systolic blood pressure, water intake, urine volume, sodium and dopamine excretion and decreased plasma aldosterone and glomerular filtration rate.
- 3.3. Administration of SCH 23390 (10mg/kg, po), but not domperidone to the high salt diet rats attenuated the diuretic effect, indicating the involvement of DA1 rather than DA2 receptors. The dopamine decarboxylase inhibitor, carbidopa (30 mg/kg, i.p.), also reduced the high salt-induced diuresis.
- 4.4. Kidney sections from rats fed the low NaCl diet showed a 63–100% decrease (P < 0.001−0.02) in cortical and medullary DA1 and DA2 binding sites, while rats fed the high NaCl diet demonstrated only a 70% decrease (P < 0.01−0.02) in cortical DA1 binding, without affecting DA2 binding.
- 5.5. These data indicate that chronic modification of dietary salt profoundly affects the sodium, water and dopamine excretion and leads to selective modulation of renal dopamine receptor subtypes.
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