Effects of chronic lithium pretreatment on apomorphine-induced penile erection |
| |
| Affiliation: | 1. Department of Pharmacology, School of Medicine, International Campus, Tehran University of Medical Sciences (TUMS-IC), 1417653861 Tehran, Iran;2. Pharmacology and Applied Medicine, Department of Medicinal Plants Research Center, Institute of Medicinal Plants, ACECR, 141554364 Karaj, Iran;3. Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, 1417614411 Tehran, Iran;4. Department of Toxicology and Pharmacology, Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran 1417614411, Iran;5. Experimental Medicine Research Center, Tehran University of Medical Sciences, 1417614411 Tehran, Iran;6. Students'' Scientific Research Center (SSRC), Tehran University of Medical Sciences, 1417614411 Tehran, Iran;7. Department of Pharmacology and Toxicology, Pharmaceutical Sciences Branch & Pharmaceutical Sciences Research Center, Islamic Azad University (IAUPS), 194193311 Tehran, Iran;8. International Campus, Tehran University of Medical Sciences, Tehran 1417614411, Iran;9. Endocrinology & Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran;1. Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran;2. Dental Research Center, Dentistry Research Institute, Tehran University of Medical Sciences, Tehran, Iran;3. Medicinal Plants Research Center, Yasuj University of Medical Sciences, Yasuj, Iran;4. Department of Medical Nanotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran;5. Division of Research and Development, Pharmin USA, LLC, San Jose, USA;6. Experimental Medicine Research Center, Tehran University of Medical Sciences, Tehran, Iran;1. Nutrition Safety Policy Division, Food Nutrition and Dietary Safety Bureau, Ministry of Food and Drug Safety, Cheongju, 361-951, Republic of Korea;2. Food and Nutrition Major, Division of Food Science and Culinary Arts, Shinhan University, Dongducheon 480-777, Republic of Korea;3. Department of Food and Nutrition, Sookmyung Women''s University, Seoul, Republic of Korea;4. Asan Institute for Life Sciences, Asan Medical Center, Seoul 138-736, Republic of Korea;1. Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran;2. Medicinal Plants Research Center, Yasuj University of Medical Sciences, Yasuj, Iran;3. Department of Anatomy, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran;4. Dental Research Center, Dentistry Research Institute, Tehran University of Medical Sciences, Tehran, Iran;5. Division of Research and Development, Pharmin USA, LLC, San Jose, USA;6. Experimental Medicine Research Center, Tehran University of Medical Sciences, Tehran, Iran |
| |
| Abstract: | - 1.1. The effects of chronic lithium pretreatment (600 mg/l in drinking rats, 30 days) on penile erection (PE) induced by apomorphine were investigated in rats. This treatment resulted in a serum Li concentration after 30 days of 0.31 ± 0.01 mmol/l.
- 2.2. Subcutaneous (s.c.) administration of mixed Dl/D2 dopamine receptor agonist apomorphine (0.05–0.5 mg/kg) induced PE in a biphasic manner. The maximum effect was obtained with 0.1 mg/kg of the drug while the response decreased with increasing doses of apomorphine from 0.1 to 0.5 mg/kg.
- 3.3. Pretreatment of animals with 0.0125-0.1 mg/kg of D1 dopamine receptor antagonist SCH 23390 or D2 dopamine receptor antagonist sulpiride (12.5–100 mg/kg) decreased apomorphine-induced PE. Combination of SCH 23390 (0.025 mg/kg) with sulpiride (12.5 mg/kg) caused a stronger inhibitory effect on apomorphine response. This indicates that both D1 and D2 dopamine receptors may be involved in PE induced by apomorphine.
- 4.4. The response induced by apomorphine (0.05-0.5 mg/kg) was decreased in animals pretreated with chronic lithium. The inhibitory effect of sulpiride on apomorphine response, increased in animals pretreated with lithium, in contrast the inhibitory effect of SCH 23390 did not change in this condition. However, a combination of SCH 23390 with sulpiride increased inhibitory effect on apomorphine response in lithium pretreated rats.
- 5.5. It is concluded that chronic lithium inhibits PE induced by dopaminergic mechanism(s).
|
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
