Sleep disorders in tuberous sclerosis: a polysomnographic study |
| |
| Affiliation: | 1. Sleep Unit, Pneumology Department, Hospital Universitario de Guadalajara, Guadalajara, Spain;2. Medicine Department, Universidad de Alcalá, Alcalá de Henares, Madrid, Spain;3. Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), Madrid, Spain;4. Pneumology Department, Hospital Universitario Ramón y Cajal, Madrid, Spain;5. Group of Translational Research in Respiratory Medicine, Hospital Universitari Arnau de Vilanova y Santa Maria, IRB Lleida, Lleida, Spain;6. Sleep Unit, Dr. J Terán Santos. Pneumology Department. Hospital Universitario de Burgos. Castilla - Leon, Spain;7. IIS Fundación Jiménez Díaz, Madrid, Spain;8. Pneumology Department, Hospital Universitario La Paz, IdiPAZ, Madrid, Spain;9. Sleep Unit, Hospital Universitario de Araba, OSI Araba, Vitoria Gasteiz, Spain;11. Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), Madrid, Spain;22. Instituto de Investigación Bioaraba, OSI Araba Hospital Universitario, Vitoria, Spain;33. Facultad de Medicina, Departamento de Medicina, Universidad del País Vasco, UPV/EHU, País Vasco, Spain;44. Centro de Investigación Biomédica en Redde Enfermedades Respiratorias (CIBERES), Madrid, Spain;55. SleepUnit, Pneumology Department, Hospital Universitario de Burgos, Burgos, Castilla-León, Spain;66. Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), Madrid, Spain;77. Group of Translational Research in Respiratory Medicine, Hospital Universitari Arnau de Vilanova y Santa Maria, IRB Lleida, Lleida, Spain;88. Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), Madrid, Spain;99. Pneumology Department, Hospital San Pedro de Alcántara, Cáceres, Spain;1010. Centro deInvestigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), Madrid, Spain;1111. Pneumology Department, Hospital Universitario Clinic-IDIBAPS, Barcelona, Spain;1. Department of Respiratory and Sleep Medicine, Angers University Hospital, Angers;2. Pays de la Loire Respiratory Health Research Institute, Beaucouzé;3. INSERM Unit 1063, Angers;4. Department of Respiratory Diseases, Le Mans General Hospital, Le Mans;5. Respiratory Unit, Pôle santé des Olonnes, Olonne sur Mer;6. Sleep Unit, Saint-Antoine Hospital, Paris;7. Department of Physiology and Sleep Medicine, Nantes University Hospital, Nantes;8. Department of Respiratory Diseases, Cholet General Hospital, Cholet;9. Department of Respiratory Diseases, La Roche sur Yon General Hospital, La Roche sur Yon;10. Respiratory Unit, Nouvelles Cliniques Nantaises, Nantes;11. Ecole Supérieure d’Electronique de l’Ouest, Angers, France;1. College of Nursing, The University of Illinois at Chicago, Chicago, IL, USA;2. Department of Spinal Surgery, Changzheng Hospital, Second Military Medical University of China, Shanghai, China;1. School of Health Sciences, College of Education, Health and Human Development, University of Canterbury, Christchurch, New Zealand;2. School of Psychology Speech & Hearing, College of Science, University of Canterbury, Christchurch, New Zealand;3. Department of Paediatrics, Canterbury District Health Board, Christchurch, New Zealand;4. Mental Health Division, Canterbury District Health Board, New Zealand |
| |
| Abstract: | Overnight polysomnography was performed in 10 subjects with tuberous sclerosis (TS) and partial epilepsy in order to investigate the relationships between sleep organization, sleep disorders and epilepsy. Sleep architecture abnormalities were observed in 9 cases. Compared with ten healthy age-matched controls, the TS group showed a shorter total sleep time, a reduced sleep efficiency, a higher number of awakenings and stage transitions, an increased wake after sleep onset and stage 1 and a decreased REM sleep. Children with seizures showed a more disrupted sleep architecture compared with seizure-free children. Sleep disorders in TS were mainly due to sleep-related epileptic events and were more evident in children who showed large bifrontal or temporal tubers on MRI. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
