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Pathogenic Potential of Eomesodermin-Expressing T-Helper Cells in Neurodegenerative Diseases |
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| Authors: | Tomomi Kanazawa MD Wakiro Sato MD PhD Ben J.E. Raveney PhD Daiki Takewaki MD Atsuko Kimura PhD Hiromi Yamaguchi BD Yuma Yokoi MD PhD Reiko Saika MD PhD Yuji Takahashi MD PhD Tsuneo Fujita MD PhD Shinji Saiki MD PhD Akira Tamaoka MD PhD Shinji Oki PhD Takashi Yamamura MD PhD |
| Affiliation: | 1. Department of Immunology, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Japan;2. Department of Immunology, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Japan Multiple Sclerosis Center, National Center Hospital, National Center of Neurology and Psychiatry, Kodaira, Japan;3. Department of Psychiatry, National Center Hospital, National Center of Neurology and Psychiatry, Tokyo, Japan;4. Department of Neurology, National Center Hospital, National Center of Neurology and Psychiatry, Tokyo, Japan;5. Department of Neurology, Hitachi General Hospital, Hitachi, Japan;6. Department of Neurology, Tsukuba University Graduate School of Medicine, Tsukuba, Japan;7. Department of Neurology, Tsukuba University Graduate School of Medicine, Tsukuba, Japan Department of Neurology, Tsukuba Memorial Hospital, Tsukuba, Japan |
| Abstract: | Eomesodermin-expressing (Eomes+) T-helper (Th) cells show cytotoxic characteristics in secondary progressive multiple sclerosis. We found that Eomes+ Th cell frequency was increased in the peripheral blood of amyotrophic lateral sclerosis and Alzheimer's disease patients. Furthermore, granzyme B production by Th cells from such patients was high compared with controls. A high frequency of Eomes+ Th cells was observed in the initial (acutely progressive) stage of amyotrophic lateral sclerosis, and a positive correlation between Eomes+ Th cell frequency and cognitive decline was observed in Alzheimer's disease patients. Therefore, Eomes+ Th cells may be involved in the pathology of amyotrophic lateral sclerosis and Alzheimer's disease. ANN NEUROL 2024;95:1093–1098 |
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