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Superoxide anion (O2-) production and bactericidal capacity of polymorphonuclear neutrophils obtained from patients subjected to glucagon test |
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| Institution: | 1. Division of Minerals and Metallurgical Engineering (MiMER), Luleå University of Technology, SE-97187 Luleå, Sweden;2. Department of Materials and Manufacturing, School of Engineering, Jönköping University, SE-55111 Jönköping, Sweden;3. Department of Chemical and Mining Engineering, University of Dar es Salaam, P.O. Box 35131, Dar es Salaam, Tanzania |
| Abstract: | Superoxide anion (O2-) production and bactericidal capacity of morphologically mature bone marrow polymorphonuclear neutrophils (PMN) were evaluated in 30 haematologically normal individuals. These same parameters of peripheral PMNs were estimated in 15 healthy volunteers before and after glucagon-induced marrow granulocyte reserve mobilization. Bone marrow PMN in comparison with cells obtained from peripheral blood manifested impaired superoxide anion production and diminished bactericidal capacity. The admixture of bone marrow PMN released into the circulation by the use of glucagon administration significantly lowered both estimated PMN functions. |
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