Effects of VA-045 on peripheral and central circulation in anesthetized dogs |
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| Institution: | 1. Nihon Bioresearch Center Inc., Gifu 501-62, Japan [Tel: 048-663-1111; Fax: 048-654-6650];2. Research Center, Taisho Pharmaceutical Co. Ltd, Saitama 330, Japan [Tel: 048-663-1111; Fax: 048-654-6650];1. Department of Botany and Microbiology, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia;2. Nanomedicine & Nanobiotechnology Lab, Department of Biosciences, Integral University, Lucknow 226026, India;3. Department of Biochemistry, Aligarh Muslim University, Aligarh 202002, U.P., India;1. State Key Laboratory of Southwestern Chinese Medicine Resources, TCM Regulating Metabolic Diseases Key Laboratory of Sichuan Province, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, China;2. Antibiotics Research and Re-evaluation Key Laboratory of Sichuan Province, Sichuan Industrial Institute of Antibiotics, Chengdu University, Chengdu, China;1. Jiangsu Key Laboratory for Functional Substance of Chinese Medicine, Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Stake Key Laboratory Cultivation Base for TCM Quality and Efficacy, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, 210023, PR China;2. State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, PR China;3. University of Chinese Academy of Sciences, Beijing, 100049, PR China;1. Department of Pharmacy Engineering, College of Chemistry and Chemical Engineering, Central South University, No.932, South Lushan Road, Changsha, Hunan, 410083, China;2. Hunan Vocational College Of Science and Technology, No.784 Jingwan Road, Changsha, Hunan, 410004, China |
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| Abstract: | - 1.1. The effects of VA-045, a novel apovincaminic acid derivative, vinpocetine, apovincaminic acid, brovincamine and nicergoline on peripheral and cerebral circulation were examined in anesthetized dogs.
- 2.2. Peripheral circulation: VA-045 induced a transient decrease in both blood pressure (BP) and heart rate (HR) and an increase in vertebral arterial blood flow (VBF) without affecting femoral arterial blood flow (FBF) or carotid arterial blood flow (CBF). Vinpocetine had no effect on BP, HR, VBF, FBF or CBF. Apovincaminic acid decreased HR and increased VBF without affecting FBF, CBF or BP. Brovincamine increased VBF and decreased CBF without affecting BP or FBF. Nicergoline decreased BP without affecting VBF, FBA or CBF.
- 3.3. Cerebral circulation: VA-045 increased cerebral blood flow (CerBF) without affecting BP. Brovincamine also increased CerBF and decreased BP. The potency of VA-045 in increasing CerBF was stronger than that of brovincamine. Vinpocetine and apovincaminic acid had no effect on BP or CerBF. Nicergoline decreased BP but did not affect CerBF.
- 4.4. These findings indicate that VA-045 has a more selective vasodilative effect on the vertebral and cerebral arteries than the other reference drugs.
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