Functional and antiischaemic effects of monoacetyl-vitexinrhamnoside in different in vitro models |
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| Affiliation: | 1. International and Inter-University Centre for Nanoscience and Nanotechnology, Mahatma Gandhi University, Kerala 686560, India;2. Department of Applied Chemistry, University of Johannesburg, South Africa;3. Centre for Nanomaterials Sciences Research, University of Johannesburg, Johannesburg, South Africa;4. School of Chemical Sciences, Mahatma Gandhi University, Kerala 686560, India;5. School of Pure and Applied Physics, Mahatma Gandhi University, Kerala 686560, India;1. School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, PR China;2. Guangdong Provincial Key Laboratory of Advanced Drug Delivery Systems and Guangdong Provincial Engineering Center of Topical Precise Drug Delivery System, Guangdong Pharmaceutical University, Guangzhou 510006, PR China;3. State Key Laboratory of Dampness Syndrome of Chinese Medicine, The second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510120, PR China |
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| Abstract: | - 1.1. Functional and antiischaemic effects of monoacetyl-vitexinrhamnoside (AVR), a flavonoid with phosphodiesterase (PDE)-inhibitory properties contained in Crataegus species (Hawthorn, Rosaceae) were studied in several in-vitro models.
- 2.2. In rabbit isolated femoral artery rings, AVR concentration-dependently reduced developed tension. Vasodilation by AVR was reduced after inhibiting EDRF formation by L-NG-nitro arginine.
- 3.3. In spontaneously-beating Langendorff-guinea pig hearts, AVR concentration-dependently enhanced heart-rate, contractility, lusitropy and coronary flow.
- 4.4. In isolated electrically-driven Langendorff-rabbit hearts, acute regional ischemia (MI) was induced by coronary artery occlusion and quantified from epicardial NADH-fluorescence photography. AVR (5 × 10−5 mol/l) induced a slight numerical increase of left ventricular pressure and coronary flow (p > 0.05). MI was reduced (p < 0.05).
- 5.5. Monoacetyl-vitexinrhamnoside is an inodilator whose vasodilatory action may be mediated in part by EDRF in addition to PDE-inhibition. Monoacetyl-vitexinrhamnoside does possess marked antiischemic properties even in isolated hearts, suggesting an improvement of myocardial perfusion.
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