Effects of adenosine analogues on apomorphine-induced penile erection in rats |
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| Institution: | 1. Division of Urology, Penn State Health Milton S. Hershey Medical Center, Mail Code H055, 500 University Drive, Hershey, PA 17033, USA;2. James Buchanan Brady Urological Institute, Johns Hopkins School of Medicine, 600 North Wolfe Street, Marburg 407, Baltimore, MD 21287, USA;1. Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA;2. Division of Oncology/Unit of Urology, IRCCS San Raffaele Hospital, Urological Research Institute, Milan, Italy;3. Urology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA;1. Medical College of Xi’an Pei Hua University, Shaanxi Xi’an 710125, China;2. Joint Laboratory of Traditional Natural Medicine, Yunnan Minzu University, Kunming, 650500, China;3. Department of pharmacy, The Second Affiliated Hospital of Fujian Medical University, Fujian, 362000, China;4. College of Life Science, Northwest University, Shaanxi Xi’an 710069, China;5. Department of Pharmacy, Xi Jing Hospital, Air Force Medical University, Shaanxi Xi’an, 710032, China;6. Department of Anesthesiology, Xi Jing Hospital, Air Force Medical University, Shaanxi Xi’an, 710032, China;7. Department of Pharmacology, China Pharmaceutical University, Nanjing, 211198, China |
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| Abstract: | - 1.1. In the present work, the effect of adenosine agonists and antagonists on apomorphine-induced penile erection (PE) has been studied.
- 2.2. Subcutaneous (s.c.) injection of the nonselective D1/D2 dopamine receptor agonist apomorphine (0.05–0.5 mg/kg) induced PE in a biphasic manner. The maximum effect was obtained with 0.1 mg/kg of the drug. The response decreased with increasing doses of apomorphine, from 0.1 to 0.5 mg/kg.
- 3.3. Intraperitoneal (i.p.) injections of adenosine agonists 5′-N-ethylcarboxamidoadenosine (NECA) and N6-cyclohexyladenosine (CHA) decreased the response of apomorphine. Apomorphine-induced PE was increased by low doses (25, 50 mg/kg, i.p.) and decreased by high doses (75, 100 mg/kg, i.p.) of the adenosine antagonist theophylline, respectively. Inhibition of PE induced by NECA and CHA was antagonized by 8-PT pretreatment.
- 4.4. Intracerebroventricular (i.c.v.) administration of CHA, NECA, and theophylline produced the same effects as i.p. injections of these agents on PE responses. It is concluded that A-1 and A-2 adenosine receptor activation may inhibit PE induced by dopaminergic mechanism(s), which can be prevented by 8-PT pretreatment.
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