Inhibitory effects of Cistus populifolius on contractile responses in the isolated rat duodenum |
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| Institution: | 1. iGent Tower, Technologiepark Zwijnaarde 15, 9052 Ghent, Belgium;2. IDLab, Department of Information Technology at Ghent University - imec, Belgium;1. University of Pittsburgh School of Medicine, Pittsburgh, PA, USA;2. Magee-Womens Research Institute and Foundation, Pittsburgh, PA, USA;3. University of Tennessee Health Science Center, Memphis, TN, USA |
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| Abstract: | The medicinal plant Cistus populifolius L., shows an important dose-dependent spasmolytic activity. The ability of the Cistus extract to inhibit both acetylcholine (ACh) (3.4 × 10−8–6.8 × 10−5 M) and CaCl2 (2 × 10−4–1.28 × 10−2 M) -induced contractions and the relaxing effect on K+ (75 mM) -induced contractions may indicate a non-specific receptor antagonist. However, this action may be related to the influx of extracellular Ca2+. These antispasmodic effects are partly consistent with the use of C. populifolius in folk medicine for certain gastrointestinal disorders. |
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